The impact of Duostim protocol on pregnancy outcomes in infertile patients: A meta-analysis comparing single and double conventional stimulation cycles

• Published in: Journal of assisted reproduction and genetics 2024-11
• Main Authors: Zeng, Youman, Liu, Weiwu, Luo, Yudi, Luo, Bowen, Zhu, Lingling, Yang, Zengyu, Feng, Keng, Li, Derong, Chen, Sheng-Ao, Li, Xiang
• Format: Article
• Language: English
• ISSN: 1573-7330; 1573-7330
• DOI: 10.1007/s10815-024-03304-5

The DuoStim protocol has been proposed as an alternative to conventional single and double stimulation cycles in the treatment of infertility. However, its efficacy in improving pregnancy outcomes remains uncertain. To systematically evaluate the impact of the DuoStim protocol on pregnancy outcomes in infertile patients by comparing it with single and double conventional stimulation cycles. An online systematic search was conducted using PubMed, Cochrane Library, and EMBASE databases, covering the period from their inception to March 2024. Randomized controlled trials (RCTs) comparing the DuoStim protocol with single and double conventional stimulation cycles in infertile patients were identified. Data were extracted by two independent investigators who screened the literature and assessed the quality of the studies. Meta-analysis was performed using RevMan 5.4 software. A total of six RCTs involving 414 infertile patients were included. The DuoStim protocol significantly increased the total number of oocytes compared to single and double conventional stimulation (MD =  - 1.47; 95% CI, - 2.12 to - 0.82; P