Heart transplantation in adults with congenital heart diseases: A comprehensive meta-analysis on waiting times, operative, and survival outcomes

The rising prevalence of congenital heart disease (CHD) among adults has led to increased heart transplantation (HT) procedures in this population. However, CHD patients face significant challenges including longer waiting times, higher early mortality rates, and increased risks of complications suc...

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Bibliographic Details
Published in:Transplantation reviews (Philadelphia, Pa.) Pa.), 2025-01, Vol.39 (1), p.100886, Article 100886
Main Authors: Banaja, Abdulaziz Abdulelah, Bulescu, Nicolae Cristian, Martin-Bonnet, Caroline, Lilot, Marc, Henaine, Roland
Format: Article
Language:English
Subjects:
Congenital heart disease
Heart transplantation
Ischemic time
Renal dysfunction
Survival rates
Waiting time
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Summary:The rising prevalence of congenital heart disease (CHD) among adults has led to increased heart transplantation (HT) procedures in this population. However, CHD patients face significant challenges including longer waiting times, higher early mortality rates, and increased risks of complications such as renal dysfunction. This systematic review and meta-analysis examined 50 studies to assess waiting times, postoperative outcomes, and survival rates in CHD patients undergoing HT compared to non-CHD patients. Results revealed that CHD patients experience longer HT waiting times (mean difference [MD]: 53.86 days, 95 % CI: [22.00, 85.72], P = 0.0009) and increased ischemic times (MD: 20.01 min, 95 % CI: [10.51, 29.51], P 
ISSN:0955-470X
1557-9816
1557-9816
DOI:10.1016/j.trre.2024.100886