Effect of age on hypnotics’ efficacy and safety in insomnia: A systematic review and meta-analysis

This systematic review and meta-analysis evaluates the efficacy in improving sleep quality and safety of hypnotics in individuals aged 65 years or older compared to those under 65 years. MEDLINE, EMBASE, Web of Science, and EBM Reviews were searched for randomized clinical trials comparing hypnotics...

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Bibliographic Details
Published in:Sleep medicine 2025-01, Vol.125, p.120-127
Main Authors: Nguyen, Patrick Viet-Quoc, Dang-Vu, Thien Thanh, Leduc, Philippe, Champagne, Sebastien, Saidi, Lidia, Desmarais, Philippe
Format: Article
Language:English
Subjects:
Age Factors
Aged
Chronic insomnia
Drug efficacy
Drug safety
Humans
Hypnotics and Sedatives - adverse effects
Hypnotics and Sedatives - therapeutic use
Meta-analysis
Randomized Controlled Trials as Topic
Sleep initiation and maintenance disorders
Sleep Initiation and Maintenance Disorders - drug therapy
Sleep Quality
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Summary:This systematic review and meta-analysis evaluates the efficacy in improving sleep quality and safety of hypnotics in individuals aged 65 years or older compared to those under 65 years. MEDLINE, EMBASE, Web of Science, and EBM Reviews were searched for randomized clinical trials comparing hypnotics to the placebo in adults with chronic insomnia between Jan 2000 and Dec 2022. The efficacy outcome included all participant self-assessments sleep quality questionnaires. The safety outcome included acceptability and tolerance. Standardized mean differences (SMD) was estimated using a random effect model. We included 17 and 53 clinical trials with 3688 and 14,720 participants in the ≥65 years and
ISSN:1389-9457
1878-5506
1878-5506
DOI:10.1016/j.sleep.2024.11.023