Prognostic Value of Endogenous-Type Coronary Microvascular Dysfunction After Elective Percutaneous Coronary Intervention

Background: Global coronary flow reserve (G-CFR) impairment represents coronary microvascular dysfunction (CMD) and correlates with poor prognosis. Hyperemic coronary flow is reduced in conventional CMD, but normal or mildly reduced with elevated resting flow in endogenous-type CMD (E-CMD). This ret...

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Bibliographic Details
Published in:Circulation Journal 2024/11/27, pp.CJ-24-0482
Main Authors: Nogami, Kai, Kanaji, Yoshihisa, Usui, Eisuke, Hada, Masahiro, Nagamine, Tatsuhiro, Ueno, Hiroki, Setoguchi, Mirei, Sayama, Kodai, Tahara, Tomohiro, Mineo, Takashi, Kakuta, Tsunekazu
Format: Article
Language:English
Subjects:
Cardiac magnetic resonance imaging
Coronary flow reserve
Coronary microvascular dysfunction
Percutaneous coronary intervention
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Summary:Background: Global coronary flow reserve (G-CFR) impairment represents coronary microvascular dysfunction (CMD) and correlates with poor prognosis. Hyperemic coronary flow is reduced in conventional CMD, but normal or mildly reduced with elevated resting flow in endogenous-type CMD (E-CMD). This retrospective study assessed the prognostic value of post-percutaneous coronary intervention (PCI) CMD, focusing on E-CMD.Methods and Results: We included 320 chronic coronary syndrome (CCS) patients undergoing PCI and post-PCI phase contrast cine-cardiac magnetic resonance imaging (CMR). Major adverse cardiac and cerebrovascular events (MACCE) were evaluated, considering the presence of post-PCI CMD and E-CMD based on G-CFR and resting myocardial flow assessed by coronary sinus flow using CMR. CMD was defined as G-CFR
ISSN:1346-9843
1347-4820
1347-4820
DOI:10.1253/circj.CJ-24-0482