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Perception of quality of life in school-age children born before 32 weeks of gestational age
Preterm infants with bronchopulmonary dysplasia (BPD) are at increased risk of disruptions in their quality of life (QoL) at school age, often associated with respiratory morbidity and the need for ongoing hospital care. The objective of this study is to assess the impact of BPD on the perceived qua...
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| Published in: | European journal of pediatrics 2024-11, Vol.184 (1), p.49 |
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| creator | Merino-Hernández, Amaia Muñoz-Cutillas, Agustin Ramos-Navarro, Cristina Bellón-Alonso, Sara Rodríguez-Cimadevilla, Juan Luis González-Pacheco, Noelia Sánchez-Luna, Manuel |
| description | Preterm infants with bronchopulmonary dysplasia (BPD) are at increased risk of disruptions in their quality of life (QoL) at school age, often associated with respiratory morbidity and the need for ongoing hospital care. The objective of this study is to assess the impact of BPD on the perceived quality of life in preterm infants at school age. We conducted a prospective observational study of infants born at less than 32 weeks gestation who were admitted to our neonatal unit between January 2012 and December 2014. These children were followed up, and at ages 8 to 10 years, their quality of life was assessed using the Pediatric Quality of Life (PedsQL) questionnaire, with higher scores indicating poorer quality of life. The study included 102 patients with a mean gestational age of 29.42 weeks (SD 1.87) and a mean birth weight of 1221.36 g (SD 347.25), with an average age of 8.59 years (SD 0.90) at the time of the survey. Patients with BPD 2–3 exhibited a significantly poorer perception of “total quality of life” (
p
= 0.03) and in the “social activities” domain (
p
= 0.02) compared to those without BPD or with BPD 1, even after adjusting for gestational age in a multivariate model. No significant differences were observed for the “health and activities” domain (
p
= 0.31), “emotional state” domain (
p
= 0.58), or “school activities” domain (
p
= 0.33). Patients who experienced asthma symptoms during follow-up had a poorer perception of total quality of life than those who did not (20.53 (SD 6.19) vs. 11.89 (SD 1.44),
p
|
| doi_str_mv | 10.1007/s00431-024-05882-z |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_3133736869</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3133736869</sourcerecordid><originalsourceid>FETCH-LOGICAL-p213t-e791e5be18da28ead4371cc5b8064d7362495eff705dd9ca786c5b4bfa84f1b63</originalsourceid><addsrcrecordid>eNpdkc1KxDAUhYMozjj6Ai6k4MZNNH9N06UM_sGALnQpIW1vZzp2mk4yRWaexmfxyUytIri5uXC_czjkIHRKySUlJLnyhAhOMWECk1gphnd7aEwFZ5iSRO6jMeGCYEnTdISOvF-SIEqpOkQjnkoiYkrH6PUJXA7tprJNZMto3Zm62mz7ta5KiKom8vnC2hqbOUT5oqoLB02UWRcGlNZBxNnnxzvAm-9Fc_Ab05uZOgqKY3RQmtrDyc87QS-3N8_Tezx7vHuYXs9wyyjfYAixIM6AqsIwBaYQPKF5HmeKSFEkXDKRxlCWCYmLIs1NomQ4iqw0SpQ0k3yCLgbf1tl1FzLoVeVzqGvTgO285pTzYKNkGtDzf-jSdi7kHSjJGI2TQJ39UF22gkK3rloZt9W_HxcAPgA-nJo5uD8bSnRfjx7q0aEe_V2P3vEvQVCAng</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3133622157</pqid></control><display><type>article</type><title>Perception of quality of life in school-age children born before 32 weeks of gestational age</title><source>Springer Link</source><creator>Merino-Hernández, Amaia ; Muñoz-Cutillas, Agustin ; Ramos-Navarro, Cristina ; Bellón-Alonso, Sara ; Rodríguez-Cimadevilla, Juan Luis ; González-Pacheco, Noelia ; Sánchez-Luna, Manuel</creator><creatorcontrib>Merino-Hernández, Amaia ; Muñoz-Cutillas, Agustin ; Ramos-Navarro, Cristina ; Bellón-Alonso, Sara ; Rodríguez-Cimadevilla, Juan Luis ; González-Pacheco, Noelia ; Sánchez-Luna, Manuel</creatorcontrib><description>Preterm infants with bronchopulmonary dysplasia (BPD) are at increased risk of disruptions in their quality of life (QoL) at school age, often associated with respiratory morbidity and the need for ongoing hospital care. The objective of this study is to assess the impact of BPD on the perceived quality of life in preterm infants at school age. We conducted a prospective observational study of infants born at less than 32 weeks gestation who were admitted to our neonatal unit between January 2012 and December 2014. These children were followed up, and at ages 8 to 10 years, their quality of life was assessed using the Pediatric Quality of Life (PedsQL) questionnaire, with higher scores indicating poorer quality of life. The study included 102 patients with a mean gestational age of 29.42 weeks (SD 1.87) and a mean birth weight of 1221.36 g (SD 347.25), with an average age of 8.59 years (SD 0.90) at the time of the survey. Patients with BPD 2–3 exhibited a significantly poorer perception of “total quality of life” (
p
= 0.03) and in the “social activities” domain (
p
= 0.02) compared to those without BPD or with BPD 1, even after adjusting for gestational age in a multivariate model. No significant differences were observed for the “health and activities” domain (
p
= 0.31), “emotional state” domain (
p
= 0.58), or “school activities” domain (
p
= 0.33). Patients who experienced asthma symptoms during follow-up had a poorer perception of total quality of life than those who did not (20.53 (SD 6.19) vs. 11.89 (SD 1.44),
p
< 0.01). No significant differences were found between patients without a diagnosis of BPD and those with grade 1 BPD. Similarly, no significant differences were observed when comparing patients of less than 28 weeks gestational age and more than 28 weeks of gestational age.
Conclusion
: In our population of preterm school-aged children with grades 2–3 BPD, worse perceived quality of life was reported compared to those with no BPD or grade 1 BPD. Preterm children who developed asthma symptoms during the follow-up period also reported lower perceived quality of life. No differences in QoL were observed between patients with no BPD and those with grade 1 BPD, or between those born before and after 28 weeks of gestation. These findings highlight the importance of assessing the QoL in preterm patients with BPD, particularly those with grade 2-3 BPD or asthma symptoms, as early assessment can help identify patients who may benefit from targeted interventions to improve quality of life and long-term outcomes.
What is Known:
•
Survival rates of extremely preterm infants have increased significantly in recent years, but respiratory morbidity, particularly bronchopulmonary dysplasia, remains a common problem. The impact of BPD on the quality of life of preterm infants, particularly at school age, is still debated. BPD is associated with an increased risk of asthma and abnormal lung function, but its effect on QoL is not fully understood.
What is New:
•
Preterm infants with grade 2-3 BPD have a significantly worse perception of QoL at school age, especially in the domain of "social activities". This finding emphasises the need for long-term follow-up and possible interventions to improve QoL, especially in terms of social integration. Asthma symptoms during childhood also contribute to poorer QoL perceptions, highlighting the importance of early diagnosis and effective treatment.</description><identifier>ISSN: 0340-6199</identifier><identifier>ISSN: 1432-1076</identifier><identifier>EISSN: 1432-1076</identifier><identifier>DOI: 10.1007/s00431-024-05882-z</identifier><identifier>PMID: 39604511</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Age ; Asthma ; Birth weight ; Bronchopulmonary Dysplasia - epidemiology ; Bronchopulmonary Dysplasia - psychology ; Child ; Children ; Diagnosis ; Dysplasia ; Female ; Follow-Up Studies ; Gestational Age ; Humans ; Infant, Newborn ; Infant, Premature ; Infants ; Lung diseases ; Male ; Medicine ; Medicine & Public Health ; Morbidity ; Neonates ; Newborn babies ; Patients ; Pediatrics ; Perceptions ; Premature babies ; Prospective Studies ; Quality of Life ; Respiratory function ; Surveys and Questionnaires ; Temporal perception ; Total quality</subject><ispartof>European journal of pediatrics, 2024-11, Vol.184 (1), p.49</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-p213t-e791e5be18da28ead4371cc5b8064d7362495eff705dd9ca786c5b4bfa84f1b63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39604511$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Merino-Hernández, Amaia</creatorcontrib><creatorcontrib>Muñoz-Cutillas, Agustin</creatorcontrib><creatorcontrib>Ramos-Navarro, Cristina</creatorcontrib><creatorcontrib>Bellón-Alonso, Sara</creatorcontrib><creatorcontrib>Rodríguez-Cimadevilla, Juan Luis</creatorcontrib><creatorcontrib>González-Pacheco, Noelia</creatorcontrib><creatorcontrib>Sánchez-Luna, Manuel</creatorcontrib><title>Perception of quality of life in school-age children born before 32 weeks of gestational age</title><title>European journal of pediatrics</title><addtitle>Eur J Pediatr</addtitle><addtitle>Eur J Pediatr</addtitle><description>Preterm infants with bronchopulmonary dysplasia (BPD) are at increased risk of disruptions in their quality of life (QoL) at school age, often associated with respiratory morbidity and the need for ongoing hospital care. The objective of this study is to assess the impact of BPD on the perceived quality of life in preterm infants at school age. We conducted a prospective observational study of infants born at less than 32 weeks gestation who were admitted to our neonatal unit between January 2012 and December 2014. These children were followed up, and at ages 8 to 10 years, their quality of life was assessed using the Pediatric Quality of Life (PedsQL) questionnaire, with higher scores indicating poorer quality of life. The study included 102 patients with a mean gestational age of 29.42 weeks (SD 1.87) and a mean birth weight of 1221.36 g (SD 347.25), with an average age of 8.59 years (SD 0.90) at the time of the survey. Patients with BPD 2–3 exhibited a significantly poorer perception of “total quality of life” (
p
= 0.03) and in the “social activities” domain (
p
= 0.02) compared to those without BPD or with BPD 1, even after adjusting for gestational age in a multivariate model. No significant differences were observed for the “health and activities” domain (
p
= 0.31), “emotional state” domain (
p
= 0.58), or “school activities” domain (
p
= 0.33). Patients who experienced asthma symptoms during follow-up had a poorer perception of total quality of life than those who did not (20.53 (SD 6.19) vs. 11.89 (SD 1.44),
p
< 0.01). No significant differences were found between patients without a diagnosis of BPD and those with grade 1 BPD. Similarly, no significant differences were observed when comparing patients of less than 28 weeks gestational age and more than 28 weeks of gestational age.
Conclusion
: In our population of preterm school-aged children with grades 2–3 BPD, worse perceived quality of life was reported compared to those with no BPD or grade 1 BPD. Preterm children who developed asthma symptoms during the follow-up period also reported lower perceived quality of life. No differences in QoL were observed between patients with no BPD and those with grade 1 BPD, or between those born before and after 28 weeks of gestation. These findings highlight the importance of assessing the QoL in preterm patients with BPD, particularly those with grade 2-3 BPD or asthma symptoms, as early assessment can help identify patients who may benefit from targeted interventions to improve quality of life and long-term outcomes.
What is Known:
•
Survival rates of extremely preterm infants have increased significantly in recent years, but respiratory morbidity, particularly bronchopulmonary dysplasia, remains a common problem. The impact of BPD on the quality of life of preterm infants, particularly at school age, is still debated. BPD is associated with an increased risk of asthma and abnormal lung function, but its effect on QoL is not fully understood.
What is New:
•
Preterm infants with grade 2-3 BPD have a significantly worse perception of QoL at school age, especially in the domain of "social activities". This finding emphasises the need for long-term follow-up and possible interventions to improve QoL, especially in terms of social integration. Asthma symptoms during childhood also contribute to poorer QoL perceptions, highlighting the importance of early diagnosis and effective treatment.</description><subject>Age</subject><subject>Asthma</subject><subject>Birth weight</subject><subject>Bronchopulmonary Dysplasia - epidemiology</subject><subject>Bronchopulmonary Dysplasia - psychology</subject><subject>Child</subject><subject>Children</subject><subject>Diagnosis</subject><subject>Dysplasia</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gestational Age</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Infant, Premature</subject><subject>Infants</subject><subject>Lung diseases</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Morbidity</subject><subject>Neonates</subject><subject>Newborn babies</subject><subject>Patients</subject><subject>Pediatrics</subject><subject>Perceptions</subject><subject>Premature babies</subject><subject>Prospective Studies</subject><subject>Quality of Life</subject><subject>Respiratory function</subject><subject>Surveys and Questionnaires</subject><subject>Temporal perception</subject><subject>Total quality</subject><issn>0340-6199</issn><issn>1432-1076</issn><issn>1432-1076</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNpdkc1KxDAUhYMozjj6Ai6k4MZNNH9N06UM_sGALnQpIW1vZzp2mk4yRWaexmfxyUytIri5uXC_czjkIHRKySUlJLnyhAhOMWECk1gphnd7aEwFZ5iSRO6jMeGCYEnTdISOvF-SIEqpOkQjnkoiYkrH6PUJXA7tprJNZMto3Zm62mz7ta5KiKom8vnC2hqbOUT5oqoLB02UWRcGlNZBxNnnxzvAm-9Fc_Ab05uZOgqKY3RQmtrDyc87QS-3N8_Tezx7vHuYXs9wyyjfYAixIM6AqsIwBaYQPKF5HmeKSFEkXDKRxlCWCYmLIs1NomQ4iqw0SpQ0k3yCLgbf1tl1FzLoVeVzqGvTgO285pTzYKNkGtDzf-jSdi7kHSjJGI2TQJ39UF22gkK3rloZt9W_HxcAPgA-nJo5uD8bSnRfjx7q0aEe_V2P3vEvQVCAng</recordid><startdate>20241128</startdate><enddate>20241128</enddate><creator>Merino-Hernández, Amaia</creator><creator>Muñoz-Cutillas, Agustin</creator><creator>Ramos-Navarro, Cristina</creator><creator>Bellón-Alonso, Sara</creator><creator>Rodríguez-Cimadevilla, Juan Luis</creator><creator>González-Pacheco, Noelia</creator><creator>Sánchez-Luna, Manuel</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7TK</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20241128</creationdate><title>Perception of quality of life in school-age children born before 32 weeks of gestational age</title><author>Merino-Hernández, Amaia ; Muñoz-Cutillas, Agustin ; Ramos-Navarro, Cristina ; Bellón-Alonso, Sara ; Rodríguez-Cimadevilla, Juan Luis ; González-Pacheco, Noelia ; Sánchez-Luna, Manuel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p213t-e791e5be18da28ead4371cc5b8064d7362495eff705dd9ca786c5b4bfa84f1b63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Age</topic><topic>Asthma</topic><topic>Birth weight</topic><topic>Bronchopulmonary Dysplasia - epidemiology</topic><topic>Bronchopulmonary Dysplasia - psychology</topic><topic>Child</topic><topic>Children</topic><topic>Diagnosis</topic><topic>Dysplasia</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gestational Age</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Infant, Premature</topic><topic>Infants</topic><topic>Lung diseases</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Morbidity</topic><topic>Neonates</topic><topic>Newborn babies</topic><topic>Patients</topic><topic>Pediatrics</topic><topic>Perceptions</topic><topic>Premature babies</topic><topic>Prospective Studies</topic><topic>Quality of Life</topic><topic>Respiratory function</topic><topic>Surveys and Questionnaires</topic><topic>Temporal perception</topic><topic>Total quality</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Merino-Hernández, Amaia</creatorcontrib><creatorcontrib>Muñoz-Cutillas, Agustin</creatorcontrib><creatorcontrib>Ramos-Navarro, Cristina</creatorcontrib><creatorcontrib>Bellón-Alonso, Sara</creatorcontrib><creatorcontrib>Rodríguez-Cimadevilla, Juan Luis</creatorcontrib><creatorcontrib>González-Pacheco, Noelia</creatorcontrib><creatorcontrib>Sánchez-Luna, Manuel</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Merino-Hernández, Amaia</au><au>Muñoz-Cutillas, Agustin</au><au>Ramos-Navarro, Cristina</au><au>Bellón-Alonso, Sara</au><au>Rodríguez-Cimadevilla, Juan Luis</au><au>González-Pacheco, Noelia</au><au>Sánchez-Luna, Manuel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Perception of quality of life in school-age children born before 32 weeks of gestational age</atitle><jtitle>European journal of pediatrics</jtitle><stitle>Eur J Pediatr</stitle><addtitle>Eur J Pediatr</addtitle><date>2024-11-28</date><risdate>2024</risdate><volume>184</volume><issue>1</issue><spage>49</spage><pages>49-</pages><issn>0340-6199</issn><issn>1432-1076</issn><eissn>1432-1076</eissn><abstract>Preterm infants with bronchopulmonary dysplasia (BPD) are at increased risk of disruptions in their quality of life (QoL) at school age, often associated with respiratory morbidity and the need for ongoing hospital care. The objective of this study is to assess the impact of BPD on the perceived quality of life in preterm infants at school age. We conducted a prospective observational study of infants born at less than 32 weeks gestation who were admitted to our neonatal unit between January 2012 and December 2014. These children were followed up, and at ages 8 to 10 years, their quality of life was assessed using the Pediatric Quality of Life (PedsQL) questionnaire, with higher scores indicating poorer quality of life. The study included 102 patients with a mean gestational age of 29.42 weeks (SD 1.87) and a mean birth weight of 1221.36 g (SD 347.25), with an average age of 8.59 years (SD 0.90) at the time of the survey. Patients with BPD 2–3 exhibited a significantly poorer perception of “total quality of life” (
p
= 0.03) and in the “social activities” domain (
p
= 0.02) compared to those without BPD or with BPD 1, even after adjusting for gestational age in a multivariate model. No significant differences were observed for the “health and activities” domain (
p
= 0.31), “emotional state” domain (
p
= 0.58), or “school activities” domain (
p
= 0.33). Patients who experienced asthma symptoms during follow-up had a poorer perception of total quality of life than those who did not (20.53 (SD 6.19) vs. 11.89 (SD 1.44),
p
< 0.01). No significant differences were found between patients without a diagnosis of BPD and those with grade 1 BPD. Similarly, no significant differences were observed when comparing patients of less than 28 weeks gestational age and more than 28 weeks of gestational age.
Conclusion
: In our population of preterm school-aged children with grades 2–3 BPD, worse perceived quality of life was reported compared to those with no BPD or grade 1 BPD. Preterm children who developed asthma symptoms during the follow-up period also reported lower perceived quality of life. No differences in QoL were observed between patients with no BPD and those with grade 1 BPD, or between those born before and after 28 weeks of gestation. These findings highlight the importance of assessing the QoL in preterm patients with BPD, particularly those with grade 2-3 BPD or asthma symptoms, as early assessment can help identify patients who may benefit from targeted interventions to improve quality of life and long-term outcomes.
What is Known:
•
Survival rates of extremely preterm infants have increased significantly in recent years, but respiratory morbidity, particularly bronchopulmonary dysplasia, remains a common problem. The impact of BPD on the quality of life of preterm infants, particularly at school age, is still debated. BPD is associated with an increased risk of asthma and abnormal lung function, but its effect on QoL is not fully understood.
What is New:
•
Preterm infants with grade 2-3 BPD have a significantly worse perception of QoL at school age, especially in the domain of "social activities". This finding emphasises the need for long-term follow-up and possible interventions to improve QoL, especially in terms of social integration. Asthma symptoms during childhood also contribute to poorer QoL perceptions, highlighting the importance of early diagnosis and effective treatment.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>39604511</pmid><doi>10.1007/s00431-024-05882-z</doi></addata></record> |
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| subjects | Age Asthma Birth weight Bronchopulmonary Dysplasia - epidemiology Bronchopulmonary Dysplasia - psychology Child Children Diagnosis Dysplasia Female Follow-Up Studies Gestational Age Humans Infant, Newborn Infant, Premature Infants Lung diseases Male Medicine Medicine & Public Health Morbidity Neonates Newborn babies Patients Pediatrics Perceptions Premature babies Prospective Studies Quality of Life Respiratory function Surveys and Questionnaires Temporal perception Total quality |
| title | Perception of quality of life in school-age children born before 32 weeks of gestational age |
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