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Exosomal noncoding RNA (ncRNA) in breast cancer pathogenesis and therapy; two sides of the same coin
Over the past few years, breast cancer has become the most prevalent type of cancer globally, with the primary cause of death from the disease being metastatic cancer. This has led to the development of early detection techniques, mainly using non-invasive biomarkers in a range of body fluids. Exoso...
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Published in: | Experimental cell research 2025-01, Vol.444 (1), p.114359, Article 114359 |
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creator | Ibrahim, Fatma Magdi Saleh, Raed Obaid Uinarni, Herlina Bokov, Dmitry Olegovich Menon, Soumya V. Zarifovich, Khamdamov Baxtiyor Misra, Neeti Al-Hamdani, Mais Mazin Husseen, Beneen Jawad, Mohammed Abed |
description | Over the past few years, breast cancer has become the most prevalent type of cancer globally, with the primary cause of death from the disease being metastatic cancer. This has led to the development of early detection techniques, mainly using non-invasive biomarkers in a range of body fluids. Exosomes are unique extracellular vesicles (EVs) transmitting cellular signals over great distances via various cargo. They are readily apparent in physiological fluids due to release by breast cancer cells or breast cancer-tumor microenvironment (TME) cells. In light of this, numerous biological and functional facets of human tumours, such as breast cancer, are intimately associated with exosomal noncoding RNAs (ncRNAs), containing miRNAs (microRNAs), lncRNAs (long noncoding RNAs), and circRNAs (circular RNAs). Exosomal ncRNAs serve a critical role in various steps of breast cancer development, enabling the exchange of genetic information between cancer cells and other cells (e.g., immune cells), thus regulating tumour angiogenesis, growth, metastasis, immune responses and drug resistance. They interact with multiple regulatory complexes with dissimilar enzymatic actions, which, in turn, modify the chromatin sceneries, including nucleosome modifications, DNA methylation, and histone modifications. Herein, we look into the exosomes' underlying regulatory mechanisms in breast cancer. Furthermore, we inspect the existing understanding of the functions of exosomal miRNAs, lncRNAs, and circRNAs in breast cancer to authenticate their possible significance in identifying biomarkers, deciphering their role in immune escape and drug resistance, and finally, analyzing treatment practices.
•Exosomes are apparent in physiological fluids as a result of release by breast cancer cells or breast cancer-tumor microenvironment (TME) cells.•They interact with multiple regulatory complexes with dissimilar enzymatic actions, which in turn, modify the chromatin sceneries.•Exosomal ncRNAs alter nucleosome modifications, DNA methylation, and histone modifications in breast cancer. |
doi_str_mv | 10.1016/j.yexcr.2024.114359 |
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•Exosomes are apparent in physiological fluids as a result of release by breast cancer cells or breast cancer-tumor microenvironment (TME) cells.•They interact with multiple regulatory complexes with dissimilar enzymatic actions, which in turn, modify the chromatin sceneries.•Exosomal ncRNAs alter nucleosome modifications, DNA methylation, and histone modifications in breast cancer.</description><identifier>ISSN: 0014-4827</identifier><identifier>ISSN: 1090-2422</identifier><identifier>EISSN: 1090-2422</identifier><identifier>DOI: 10.1016/j.yexcr.2024.114359</identifier><identifier>PMID: 39608481</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Biomarkers, Tumor - genetics ; Biomarkers, Tumor - metabolism ; Breast cancer ; Breast Neoplasms - genetics ; Breast Neoplasms - pathology ; Exosome ; Exosomes - genetics ; Exosomes - metabolism ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Immune responses ; MicroRNAs - genetics ; Noncoding RNA (ncRNA) ; Pathogenesis ; RNA, Circular - genetics ; RNA, Circular - metabolism ; RNA, Long Noncoding - genetics ; RNA, Untranslated - genetics ; Tumor Microenvironment - genetics</subject><ispartof>Experimental cell research, 2025-01, Vol.444 (1), p.114359, Article 114359</ispartof><rights>2024 Elsevier Inc.</rights><rights>Copyright © 2024 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c1541-25ec540045f6532acc8e450a72f281c11d8a07510bba490f11a83dc2111d49443</cites><orcidid>0009-0004-1238-378X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39608481$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ibrahim, Fatma Magdi</creatorcontrib><creatorcontrib>Saleh, Raed Obaid</creatorcontrib><creatorcontrib>Uinarni, Herlina</creatorcontrib><creatorcontrib>Bokov, Dmitry Olegovich</creatorcontrib><creatorcontrib>Menon, Soumya V.</creatorcontrib><creatorcontrib>Zarifovich, Khamdamov Baxtiyor</creatorcontrib><creatorcontrib>Misra, Neeti</creatorcontrib><creatorcontrib>Al-Hamdani, Mais Mazin</creatorcontrib><creatorcontrib>Husseen, Beneen</creatorcontrib><creatorcontrib>Jawad, Mohammed Abed</creatorcontrib><title>Exosomal noncoding RNA (ncRNA) in breast cancer pathogenesis and therapy; two sides of the same coin</title><title>Experimental cell research</title><addtitle>Exp Cell Res</addtitle><description>Over the past few years, breast cancer has become the most prevalent type of cancer globally, with the primary cause of death from the disease being metastatic cancer. This has led to the development of early detection techniques, mainly using non-invasive biomarkers in a range of body fluids. Exosomes are unique extracellular vesicles (EVs) transmitting cellular signals over great distances via various cargo. They are readily apparent in physiological fluids due to release by breast cancer cells or breast cancer-tumor microenvironment (TME) cells. In light of this, numerous biological and functional facets of human tumours, such as breast cancer, are intimately associated with exosomal noncoding RNAs (ncRNAs), containing miRNAs (microRNAs), lncRNAs (long noncoding RNAs), and circRNAs (circular RNAs). Exosomal ncRNAs serve a critical role in various steps of breast cancer development, enabling the exchange of genetic information between cancer cells and other cells (e.g., immune cells), thus regulating tumour angiogenesis, growth, metastasis, immune responses and drug resistance. They interact with multiple regulatory complexes with dissimilar enzymatic actions, which, in turn, modify the chromatin sceneries, including nucleosome modifications, DNA methylation, and histone modifications. Herein, we look into the exosomes' underlying regulatory mechanisms in breast cancer. Furthermore, we inspect the existing understanding of the functions of exosomal miRNAs, lncRNAs, and circRNAs in breast cancer to authenticate their possible significance in identifying biomarkers, deciphering their role in immune escape and drug resistance, and finally, analyzing treatment practices.
•Exosomes are apparent in physiological fluids as a result of release by breast cancer cells or breast cancer-tumor microenvironment (TME) cells.•They interact with multiple regulatory complexes with dissimilar enzymatic actions, which in turn, modify the chromatin sceneries.•Exosomal ncRNAs alter nucleosome modifications, DNA methylation, and histone modifications in breast cancer.</description><subject>Animals</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - genetics</subject><subject>Breast Neoplasms - pathology</subject><subject>Exosome</subject><subject>Exosomes - genetics</subject><subject>Exosomes - metabolism</subject><subject>Female</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Humans</subject><subject>Immune responses</subject><subject>MicroRNAs - genetics</subject><subject>Noncoding RNA (ncRNA)</subject><subject>Pathogenesis</subject><subject>RNA, Circular - genetics</subject><subject>RNA, Circular - metabolism</subject><subject>RNA, Long Noncoding - genetics</subject><subject>RNA, Untranslated - genetics</subject><subject>Tumor Microenvironment - genetics</subject><issn>0014-4827</issn><issn>1090-2422</issn><issn>1090-2422</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2025</creationdate><recordtype>article</recordtype><recordid>eNp9kE1rGzEQhkVJaZy0v6BQdHQO685IWltLycGEfBRMAqU9C1maTWS8kiOtk_jfZ10nPfY0MPN-MA9jXxEmCDj9vprs6MXliQChJohK1s0HNkJooBJKiCM2AkBVKS1mx-yklBUAaI3TT-xYNlPQSuOI-cuXVFJn1zym6JIP8Z7_up3zcXTDOOMh8mUmW3rubHSU-cb2D-meIpVQuI2e9w-U7Wb3g_fPiZfgqfDU7re82I64SyF-Zh9buy705W2esj9Xl78vbqrF3fXPi_miclgrrERNrlYAqm6ntRTWOU2qBjsTrdDoEL22MKsRlkurGmgRrZbeCRwuqlFKnrLxIXeT0-OWSm-6UByt1zZS2hYjUSoYomdykMqD1OVUSqbWbHLobN4ZBLPHa1bmL16zx2sOeAfXt7eC7bIj_8_zznMQnB8ENLz5FCib4gIN4HzI5HrjU_hvwSvnCYq0</recordid><startdate>20250101</startdate><enddate>20250101</enddate><creator>Ibrahim, Fatma Magdi</creator><creator>Saleh, Raed Obaid</creator><creator>Uinarni, Herlina</creator><creator>Bokov, Dmitry Olegovich</creator><creator>Menon, Soumya V.</creator><creator>Zarifovich, Khamdamov Baxtiyor</creator><creator>Misra, Neeti</creator><creator>Al-Hamdani, Mais Mazin</creator><creator>Husseen, Beneen</creator><creator>Jawad, Mohammed Abed</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0009-0004-1238-378X</orcidid></search><sort><creationdate>20250101</creationdate><title>Exosomal noncoding RNA (ncRNA) in breast cancer pathogenesis and therapy; two sides of the same coin</title><author>Ibrahim, Fatma Magdi ; Saleh, Raed Obaid ; Uinarni, Herlina ; Bokov, Dmitry Olegovich ; Menon, Soumya V. ; Zarifovich, Khamdamov Baxtiyor ; Misra, Neeti ; Al-Hamdani, Mais Mazin ; Husseen, Beneen ; Jawad, Mohammed Abed</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1541-25ec540045f6532acc8e450a72f281c11d8a07510bba490f11a83dc2111d49443</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2025</creationdate><topic>Animals</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - genetics</topic><topic>Breast Neoplasms - pathology</topic><topic>Exosome</topic><topic>Exosomes - genetics</topic><topic>Exosomes - metabolism</topic><topic>Female</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Humans</topic><topic>Immune responses</topic><topic>MicroRNAs - genetics</topic><topic>Noncoding RNA (ncRNA)</topic><topic>Pathogenesis</topic><topic>RNA, Circular - genetics</topic><topic>RNA, Circular - metabolism</topic><topic>RNA, Long Noncoding - genetics</topic><topic>RNA, Untranslated - genetics</topic><topic>Tumor Microenvironment - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ibrahim, Fatma Magdi</creatorcontrib><creatorcontrib>Saleh, Raed Obaid</creatorcontrib><creatorcontrib>Uinarni, Herlina</creatorcontrib><creatorcontrib>Bokov, Dmitry Olegovich</creatorcontrib><creatorcontrib>Menon, Soumya V.</creatorcontrib><creatorcontrib>Zarifovich, Khamdamov Baxtiyor</creatorcontrib><creatorcontrib>Misra, Neeti</creatorcontrib><creatorcontrib>Al-Hamdani, Mais Mazin</creatorcontrib><creatorcontrib>Husseen, Beneen</creatorcontrib><creatorcontrib>Jawad, Mohammed Abed</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental cell research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ibrahim, Fatma Magdi</au><au>Saleh, Raed Obaid</au><au>Uinarni, Herlina</au><au>Bokov, Dmitry Olegovich</au><au>Menon, Soumya V.</au><au>Zarifovich, Khamdamov Baxtiyor</au><au>Misra, Neeti</au><au>Al-Hamdani, Mais Mazin</au><au>Husseen, Beneen</au><au>Jawad, Mohammed Abed</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exosomal noncoding RNA (ncRNA) in breast cancer pathogenesis and therapy; two sides of the same coin</atitle><jtitle>Experimental cell research</jtitle><addtitle>Exp Cell Res</addtitle><date>2025-01-01</date><risdate>2025</risdate><volume>444</volume><issue>1</issue><spage>114359</spage><pages>114359-</pages><artnum>114359</artnum><issn>0014-4827</issn><issn>1090-2422</issn><eissn>1090-2422</eissn><abstract>Over the past few years, breast cancer has become the most prevalent type of cancer globally, with the primary cause of death from the disease being metastatic cancer. This has led to the development of early detection techniques, mainly using non-invasive biomarkers in a range of body fluids. Exosomes are unique extracellular vesicles (EVs) transmitting cellular signals over great distances via various cargo. They are readily apparent in physiological fluids due to release by breast cancer cells or breast cancer-tumor microenvironment (TME) cells. In light of this, numerous biological and functional facets of human tumours, such as breast cancer, are intimately associated with exosomal noncoding RNAs (ncRNAs), containing miRNAs (microRNAs), lncRNAs (long noncoding RNAs), and circRNAs (circular RNAs). Exosomal ncRNAs serve a critical role in various steps of breast cancer development, enabling the exchange of genetic information between cancer cells and other cells (e.g., immune cells), thus regulating tumour angiogenesis, growth, metastasis, immune responses and drug resistance. They interact with multiple regulatory complexes with dissimilar enzymatic actions, which, in turn, modify the chromatin sceneries, including nucleosome modifications, DNA methylation, and histone modifications. Herein, we look into the exosomes' underlying regulatory mechanisms in breast cancer. Furthermore, we inspect the existing understanding of the functions of exosomal miRNAs, lncRNAs, and circRNAs in breast cancer to authenticate their possible significance in identifying biomarkers, deciphering their role in immune escape and drug resistance, and finally, analyzing treatment practices.
•Exosomes are apparent in physiological fluids as a result of release by breast cancer cells or breast cancer-tumor microenvironment (TME) cells.•They interact with multiple regulatory complexes with dissimilar enzymatic actions, which in turn, modify the chromatin sceneries.•Exosomal ncRNAs alter nucleosome modifications, DNA methylation, and histone modifications in breast cancer.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>39608481</pmid><doi>10.1016/j.yexcr.2024.114359</doi><orcidid>https://orcid.org/0009-0004-1238-378X</orcidid></addata></record> |
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subjects | Animals Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Breast cancer Breast Neoplasms - genetics Breast Neoplasms - pathology Exosome Exosomes - genetics Exosomes - metabolism Female Gene Expression Regulation, Neoplastic Humans Immune responses MicroRNAs - genetics Noncoding RNA (ncRNA) Pathogenesis RNA, Circular - genetics RNA, Circular - metabolism RNA, Long Noncoding - genetics RNA, Untranslated - genetics Tumor Microenvironment - genetics |
title | Exosomal noncoding RNA (ncRNA) in breast cancer pathogenesis and therapy; two sides of the same coin |
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