Pediatric, adult, and late-onset multiple sclerosis patients: A unified analysis of clinical profiles and treatment responses

•Analysis of clinical profiles and treatments in POMS, AOMS, and LOMS.•LOMS patients show progressive onset and higher disability scores.•Treatment shifts to second-line therapies, especially in LOMS patients.•Patients with PIRA more likely to have SPMS and higher disability progression.•Oligoclonal...

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Bibliographic Details
Published in:Multiple sclerosis and related disorders 2025-01, Vol.93, p.106184, Article 106184
Main Authors: Tunç, Abdulkadir, Seferoğlu, Meral, SIVACI, Ali Özhan, Köktürk, Mevrehan Dilber, POLAT, Ayşe Kristina
Format: Article
Language:English
Subjects:
Adult-onset multiple sclerosis
Clinical characteristics
Late-onset multiple sclerosis
Pediatric-onset multiple sclerosis
Treatment response
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Summary:•Analysis of clinical profiles and treatments in POMS, AOMS, and LOMS.•LOMS patients show progressive onset and higher disability scores.•Treatment shifts to second-line therapies, especially in LOMS patients.•Patients with PIRA more likely to have SPMS and higher disability progression.•Oligoclonal band positivity consistent across all age groups. This study aimed to conduct a unified analysis comparing the clinical characteristics, disease progression, and treatment responses of pediatric-onset multiple sclerosis (POMS), adult-onset multiple sclerosis (AOMS), and late-onset multiple sclerosis (LOMS) patients. Utilizing a retrospective cohort design, we analyzed the records of 269 patients from MS clinics and categorized them into the POMS (
ISSN:2211-0348
2211-0356
2211-0356
DOI:10.1016/j.msard.2024.106184