Minimally invasive surgery versus open surgery in advanced stage endometrial cancer

• Published in: The journal of obstetrics and gynaecology research 2025-01, Vol.51 (1), p.e16179
• Main Authors: Lee, Jimin, Kim, Jeeyeon, Son, Joo-Hyuk, Kong, Tae-Wook, Paek, Jiheum, Chang, Suk-Joon
• Format: Article
• Language: English
• Subjects: Adult; Aged; Disease-Free Survival; Endometrial Neoplasms - mortality; Endometrial Neoplasms - pathology; Endometrial Neoplasms - surgery; Female; Humans; Middle Aged; Minimally Invasive Surgical Procedures - methods; Neoplasm Staging; Retrospective Studies
• ISSN: 1447-0756; 1447-0756
• DOI: 10.1111/jog.16179

Staging surgery in early stage endometrial cancer has been shown to be feasible and safe with minimally invasive surgery (MIS) in many previous studies. However, there is limited literature on MIS's safety in advanced stages. This study aims to identify factors associated with survival in stage III endometrial cancer and investigate survival differences based on surgical approach. Patients with stage III endometrial cancer who underwent staging surgery from March 2002 to March 2023 were included in this study. Various clinicopathological features, disease-free survival (DFS), and overall survival (OS) were evaluated. Among the 79 patients included in this study, 20 patients underwent MIS (25.3%) and 59 patients underwent open surgery (74.7%). The open surgery group had a higher prevalence of aggressive histology, a higher median pretreatment CA-125 level, and a greater number of harvested lymph nodes compared to the MIS group. Five-year OS and DFS was higher in the open surgery group than in the MIS group (DFS: 67.9% vs. 59.9%, p = 0.046; OS: 74.3 vs. 50.6%, p = 0.008). In multivariate analysis, younger than 55 years old (OR, 2.778; 95% CI, 1.078-7.156; p = 0.034), and open surgery (OR, 3.671; 95% CI, 1.581-8.522; p = 0.002) was related to improved OS. Open staging surgery showed better survival outcomes when compared to MIS in stage III endometrial cancer patients in our study. For patients who are older than 55 years old and have aggressive histology in endometrial biopsy, considering open surgery may help improve their prognosis, even if preoperative MRI suggests early-stage endometrial cancer.