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Involvement of necroptosıs and apoptosıs ın protectıve effects of cyclosporın a on ischemıa-reperfusıon injury in rat kıdney

We aimed to investigate the protective effects of low dose cyclosporin A (CsA) on ischemia–reperfusion (IR) injury in rat the kidney and on the apoptotic and necroptotic mechanisms involved. 1. Control group (received a single intraperitoneal (i.p.) dose of 1 ml sterile saline 15 min before the surg...

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Published in:Journal of molecular histology 2025-02, Vol.56 (1), p.30
Main Authors: Ozgen, Zeynep Erdogmus, Erdinc, Meral, Kaya, Meryem Seyda, Aktar, Fesih, Ozekinci, Selver Ozsener, Erdinc, Levent, Uyar, Emre
Format: Article
Language:English
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Summary:We aimed to investigate the protective effects of low dose cyclosporin A (CsA) on ischemia–reperfusion (IR) injury in rat the kidney and on the apoptotic and necroptotic mechanisms involved. 1. Control group (received a single intraperitoneal (i.p.) dose of 1 ml sterile saline 15 min before the surgical procedure), 2. IR group (was subjected to 30 min of bilateral kidney ischemia followed by 90 min of reperfusion; and received a single i.p. dose of 1 ml sterile saline 15 min before the IR procedure, 3. IR + CsA group (received a single i.p. dose of 3 mg/kg CsA 15 min before the IR procedure. Renal functions (renal perfusion pressures, and serum urea-creatinine levels), kidney histological scores, MDA levels, and TNF-α, caspase-3, RIP1, RIP3, MLKL, CaMKII and CypD protein expressions were also measured. Renal perfusion pressures (PP), serum urea and creatinine levels, renal tissue MDA levels, and the protein expression levels of TNF-α, caspase-3, RIP1, RIP3, MLKL, CAMKII and CypD were significantly increased in the IR group compared to the control group (p 
ISSN:1567-2379
1567-2387
1567-2387
DOI:10.1007/s10735-024-10281-7