The impact of metabolic health on fibromyalgia: insights from insulin resistance and related indexes

To assess the association between fibromyalgia (FM) and insulin resistance (IR) using multiple IR indices in FM patients and to investigate how these indices vary with the severity of FM. This cross-sectional study included 70 female patients diagnosed with FM and 70 age-matched female healthy contr...

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Bibliographic Details
Published in:Postgraduate medicine 2025-01, Vol.137 (1), p.1-36
Main Authors: Tunç Karaman, Sibel, Hüner, Berrin, Basat, Okcan
Format: Article
Language:English
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Summary:To assess the association between fibromyalgia (FM) and insulin resistance (IR) using multiple IR indices in FM patients and to investigate how these indices vary with the severity of FM. This cross-sectional study included 70 female patients diagnosed with FM and 70 age-matched female healthy controls. The data collected included demographics, clinical characteristics, and laboratory parameters. FM severity was evaluated using the Fibromyalgia Impact Questionnaire-Revised (FIQR). The metabolic indices calculated were the Homeostasis Model Assessment of Insulin Resistance (HOMA-IR), Quantitative Insulin Sensitivity Check Index (QUICKI), triglyceride - glucose index (TyG), triglyceride to HDL cholesterol ratio (TG/HDL-C), and Metabolic Score for Insulin Resistance (METS-IR). FM patients exhibited significantly higher HOMA-IR values (  = 0.002), and lower QUICKI values (  = 0.000) than controls. METS-IR also showed significant differences between FM patients and controls (  = 0.026). HOMA-IR and METS-IR values increased with FM severity, whereas QUICKI values decreased (  
ISSN:0032-5481
1941-9260
1941-9260
DOI:10.1080/00325481.2024.2439244