Characterization of tea polysaccharides from Tieguanyin oolong tea and their hepatoprotective effects via AMP‐activated protein kinase–mediated signaling pathways

In the present study, we succeeded in extracting tea polysaccharide (TPS) from Tieguanyin oolong tea, and the TPS was characterized. TPS is an acidic heteropolysaccharide containing rhamnose, arabinose, galactose, glucose (Glc), xylose, mannose, galacturonic acid, and guluronic acid. We found that T...

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Bibliographic Details
Published in:Journal of food science 2024-12, Vol.89 (12), p.10064-10078
Main Authors: Chen, Yiqin, Huang, Yanxin, Gan, Qiaorong, Zhang, Wenhui, Sun, Han, Zhu, Lingling, Wang, Wenxiang
Format: Article
Language:English
Subjects:
Acetyl-CoA Carboxylase - genetics
Acetyl-CoA Carboxylase - metabolism
Adenosine
Adenosine kinase
Alanine
Alanine transaminase
Alanine Transaminase - blood
Alanine Transaminase - metabolism
AMP
AMP-activated protein kinase
AMP-Activated Protein Kinases - genetics
AMP-Activated Protein Kinases - metabolism
Animals
Arabinose
Camellia sinensis - chemistry
Cholesterol
Coenzyme A
Diet, High-Fat - adverse effects
Fatty liver
Galactose
Genes
hepatoprotective effects
High cholesterol diet
High fat diet
Kinases
Liver
Liver - drug effects
Liver - metabolism
Liver diseases
Male
Mannose
Mice
Mice, Inbred C57BL
Non-alcoholic Fatty Liver Disease - etiology
Non-alcoholic Fatty Liver Disease - prevention & control
nonalcoholic fatty liver disease
Nutrient deficiency
Oolong tea
Plant Extracts - pharmacology
Polysaccharides
Polysaccharides - pharmacology
Protective Agents - pharmacology
Protein kinase
Proteins
Saccharides
Signal transduction
Signal Transduction - drug effects
SIRT1 protein
Sirtuin 1 - genetics
Sirtuin 1 - metabolism
Steatosis
Sterol Regulatory Element Binding Protein 1 - genetics
Sterol Regulatory Element Binding Protein 1 - metabolism
Tea
Tea - chemistry
tea polysaccharides
Triglycerides
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Summary:In the present study, we succeeded in extracting tea polysaccharide (TPS) from Tieguanyin oolong tea, and the TPS was characterized. TPS is an acidic heteropolysaccharide containing rhamnose, arabinose, galactose, glucose (Glc), xylose, mannose, galacturonic acid, and guluronic acid. We found that TPS supplementation partially reversed the elevated levels of serum alanine aminotransferase, total cholesterol, and low‐density lipoprotein cholesterol in high‐fat diet (HD)‐induced nonalcoholic fatty liver disease (NAFLD) mice (p 
ISSN:0022-1147
1750-3841
1750-3841
DOI:10.1111/1750-3841.17575