Non-vesicular extracellular RNA: A potential drug target to intervene cell-cell communication

The importance of non-vesicular extracellular RNA in the mammalian system is becoming increasingly apparent. Non-vesicular extracellular RNA is defined as RNA molecules not included in a lipid bilayer such as exosomes. Because non-vesicular extracellular RNA is not protected from RNases and is there...

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Bibliographic Details
Published in:Pharmacology & therapeutics (Oxford) 2025-02, Vol.266, p.108774, Article 108774
Main Author: Tomita, Takeshi
Format: Article
Language:English
Subjects:
AU-rich element
Exomeres
Extracellular vesicles
Non-vesicular extracellular RNA
Supermeres
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Summary:The importance of non-vesicular extracellular RNA in the mammalian system is becoming increasingly apparent. Non-vesicular extracellular RNA is defined as RNA molecules not included in a lipid bilayer such as exosomes. Because non-vesicular extracellular RNA is not protected from RNases and is therefore rapidly degraded, they were not easily captured by conventional biofluid analyses. Recent publications showed that some non-vesicular extracellular RNAs are relatively stable in biofluids or tissue culture media, and they have unique biological functions. Major RNAs (rRNA, mRNA, and tRNA) and other non-cording RNAs play important roles in transcription or translation in the cell. In contrast, non-vesicular extracellular RNA has functions related to intercellular communication rather than protein synthesis. This review discusses the basics of non-vesicular extracellular RNA, including its definition, purification, receptors, and future prospects as a drug target.
ISSN:0163-7258
1879-016X
1879-016X
DOI:10.1016/j.pharmthera.2024.108774