The effects of whey protein supplementation on indices of cardiometabolic health: A systematic review and meta-analysis of randomized controlled trials

The increasing prevalence of cardiometabolic diseases highlights the urgent need for practical interventions to mitigate their associated public health burden. Whey protein supplementation has emerged as a potential intervention for improving markers of cardiometabolic health. The aim of this system...

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Published in:Clinical nutrition (Edinburgh, Scotland) Scotland), 2025-01, Vol.44, p.109-121
Main Authors: Prokopidis, Konstantinos, Morgan, Paul T., Veronese, Nicola, Morwani-Mangnani, Jordi, Triantafyllidis, Konstantinos K., Kechagias, Konstantinos S., Roberts, Justin, Hurst, Christopher, Stevenson, Emma, Vlachopoulos, Dimitris, Witard, Oliver C.
Format: Article
Language:English
Subjects:
Blood pressure
Cardiometabolic disease
Insulin resistance
Lipoprotein profile
Whey protein
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Summary:The increasing prevalence of cardiometabolic diseases highlights the urgent need for practical interventions to mitigate their associated public health burden. Whey protein supplementation has emerged as a potential intervention for improving markers of cardiometabolic health. The aim of this systematic review and meta-analysis was to examine the effect of whey protein ingestion on cardiometabolic profile in adults. A systematic search was conducted in PubMed, Web of Science, Scopus, and Cochrane Library from inception until June 2024. Eligible RCTs compared the effect of whey protein supplementation compared to placebo or a carbohydrate-based control on markers of cardiometabolic health. Using the random effects inverse-variance model, we estimated the mean difference (MD) in blood pressure, high- and low-density lipoproteins (HDL-cholesterol, LDL-cholesterol), total cholesterol, triglycerides, and homeostatic model assessment for insulin resistance (HOMA-IR) index. This meta-analysis included 21 RCTs. Whey protein supplementation had no effect on HDL-cholesterol concentration but did elicit a reduction in LDL-cholesterol in individuals aged
ISSN:0261-5614
1532-1983
1532-1983
DOI:10.1016/j.clnu.2024.12.003