Impact of Fasciola hepatica Infection and Triclabendazole Treatment on Humoral Immune Response in Cattle

ABSTRACT Fasciola hepatica is a trematode parasite of significant veterinary and public health importance, causing economic losses in livestock due to liver damage, weight loss and reduced milk production. Although triclabendazole (TCZ) is available for treatment, it does not prevent the disease or...

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Bibliographic Details
Published in:Parasite immunology 2024-12, Vol.46 (12), p.e13079-n/a
Main Authors: Costa, Monique, Saravia, Anderson, Ubios, Diego, Paolazzi, Claudio, Capozzo, Alejandra, Freire, Teresa
Format: Article
Language:English
Subjects:
Animals
Anthelmintics - therapeutic use
Antibodies
Antibodies, Bacterial - blood
Antibodies, Helminth - blood
antibody
Antibody response
Avidity
Bacterial Vaccines - immunology
Cattle
Cattle Diseases - drug therapy
Cattle Diseases - immunology
Cattle Diseases - parasitology
Cattle Diseases - prevention & control
Chronic infection
Cow's milk
Fasciola hepatica
Fasciola hepatica - immunology
Fascioliasis - drug therapy
Fascioliasis - immunology
Fascioliasis - prevention & control
Fascioliasis - veterinary
Feces
Feces - parasitology
Immune response (humoral)
Immunity, Humoral - drug effects
immunomodulation
Immunoregulation
Infections
Livestock
Male
Milk production
Public health
Triclabendazole - immunology
Triclabendazole - therapeutic use
vaccine
Vaccines
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Summary:ABSTRACT Fasciola hepatica is a trematode parasite of significant veterinary and public health importance, causing economic losses in livestock due to liver damage, weight loss and reduced milk production. Although triclabendazole (TCZ) is available for treatment, it does not prevent the disease or reinfection. Infected animals exhibit strong immunoregulation, increasing susceptibility to secondary infections and altering vaccine‐induced antibody responses. This study investigates the humoral immune response in cattle infected with F. hepatica at different stages of infection and evaluates the effect of TCZ treatment on this response. It also examines how fasciolosis affects the antibody response induced by bacterial vaccines during early and chronic infection stages. Experimental infections in steers were conducted, with faecal and plasma samples collected at various intervals. The results showed a decrease in parasite‐specific antibody avidity during infection. However, F. hepatica infection did not substantially modify antibody response to bacterial vaccines. This study underscores the need for further research on the impact of fasciolosis and its treatment on livestock vaccination efficacy.
ISSN:0141-9838
1365-3024
1365-3024
DOI:10.1111/pim.13079