Assessment of sedative activity of Chrysin: Behavioral approach with pharmacokinetics, toxicological profile and molecular docking

The purpose of this study was to investigate the sedative effects of Chrysin (CHR) along with modulatory effects on diazepam (DZP) and flumazenil (FLU) in an animal sleep model produced by thiopental sodium (TS). Additionally, we explored the pharmacokinetics and potential GABAA receptor interaction...

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Bibliographic Details
Published in:Sleep medicine 2025-02, Vol.126, p.88-96
Main Authors: Al Hasan, Md Sakib, Bhuia, Md Shimul, Sheikh, Salehin, Bithi, Sumaya Akter, Saim, Md Abu, Kamli, Hossam, Ansari, Siddique Akber, Ahammed, Nowreen Tabassum, Islam, Muhammad Torequl
Format: Article
Language:English
Subjects:
Chrysin
GABAA receptor
Insomnia
Molecular docking
Pharmacokinetics
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Summary:The purpose of this study was to investigate the sedative effects of Chrysin (CHR) along with modulatory effects on diazepam (DZP) and flumazenil (FLU) in an animal sleep model produced by thiopental sodium (TS). Additionally, we explored the pharmacokinetics and potential GABAA receptor interactions of CHR through computational studies. Swiss albino mice were treated with intraperitoneal administration of CHR (5 and 10 mg/kg), DZP (2 mg/kg), and FLU (0.1 mg/kg) either alone or in combination. Sleeping onset and duration were measured following TS administration. Molecular docking was performed to investigate CHR's binding affinity with GABAA (PDB: 6X3X) receptors. Results found that CHR significantly (p 
ISSN:1389-9457
1878-5506
1878-5506
DOI:10.1016/j.sleep.2024.12.007