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Assessment of Subacute Toxicity of Ulexite in Rats: Behavioral, Hematological, and Biochemical Insights

Ulexite (UX), a naturally occurring borate mineral, has gained interest for its diverse industrial applications, yet its toxicological profile remains inadequately characterized. This study aimed to evaluate the subacute toxicity of UX in rats, focusing on behavioral, hematological, and biochemical...

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Bibliographic Details
Published in:Biological trace element research 2024-12
Main Authors: Türkez, Hasan, Özdemir Tozlu, Özlem, Yıldız, Edanur, Saraçoğlu, Melik, Baba, Cem, Çınar, Burak, Yıldırım, Serkan, Kılıçlıoğlu, Metin, Topkara, Kübra Çelik, Çadırcı, Kenan
Format: Article
Language:English
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Summary:Ulexite (UX), a naturally occurring borate mineral, has gained interest for its diverse industrial applications, yet its toxicological profile remains inadequately characterized. This study aimed to evaluate the subacute toxicity of UX in rats, focusing on behavioral, hematological, and biochemical parameters. Rats were administered UX via gavage at doses of 10, 30, and 300 mg/kg for 7 days. No mortality or significant signs of toxicity were observed, although body weight measurements indicated a notable reduction in the UX-treated groups compared to controls. Behavioral assessments demonstrated increased exploratory activity in the 10 and 300 mg/kg UX treated groups, suggesting low anxiety levels. Likewise, hematological analysis revealed that 30 and 300 mg/kg UX led a significant (P 
ISSN:0163-4984
1559-0720
1559-0720
DOI:10.1007/s12011-024-04489-7