Precocious Puberty in Children with Neurofibromatosis Type 1

This multi-institutional, descriptive study of 19 children with neurofibromatosis 1 examines the link between optic pathway gliomas (OPGs) and central precocious puberty (CPP). We report that CPP can arise without OPG chiasmal involvement and that prior OPG chemotherapy does not prevent the developm...

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Bibliographic Details
Published in:The Journal of pediatrics 2024-12, p.114440, Article 114440
Main Authors: Katz, Julia, Ratnam, Sarayu, Listernick, Robert H., Habiby, Reema L., Gutmann, David H.
Format: Article
Language:English
Online Access:Get full text
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Summary:This multi-institutional, descriptive study of 19 children with neurofibromatosis 1 examines the link between optic pathway gliomas (OPGs) and central precocious puberty (CPP). We report that CPP can arise without OPG chiasmal involvement and that prior OPG chemotherapy does not prevent the development of CPP.
ISSN:0022-3476
1097-6833
1097-6833
DOI:10.1016/j.jpeds.2024.114440