Natural killer cells: a new promising source for developing chimeric antigen receptor anti-cancer cells in hematological malignancies

In recent times, the application of CAR-T cell treatment has significantly progressed, showing auspicious treatment outcomes in hematologic malignancies. However, along with these advances, certain limitations and challenges hurdle the widespread utilization of this technology. Recently, CAR-NK cell...

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Bibliographic Details
Published in:Leukemia & lymphoma 2024-12, p.1
Main Authors: Mousavi, Shahrzad, Khazaee-Nasirabadi, Mohammad Hossein, Seyedmehdi, Maryam Sadat, Bazi, Ali, Mirzaee Khalilabadi, Roohollah
Format: Article
Language:English
Online Access:Get full text
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Summary:In recent times, the application of CAR-T cell treatment has significantly progressed, showing auspicious treatment outcomes in hematologic malignancies. However, along with these advances, certain limitations and challenges hurdle the widespread utilization of this technology. Recently, CAR-NK cells have gained attention in cancer treatment, as this approach has an important advantage over CART therapy (i.e. no need for HLA matching) for targeting foreign cells. This review aims to explore the benefits of CAR NK cell therapy, and generation strategies, as well as the challenges and limitations hindering the application of CAR NK cells in experimental studies and trials on hematologic malignancies.
ISSN:1029-2403
1029-2403
DOI:10.1080/10428194.2024.2438802