Lateralization outcomes of bilateral inferior petrosal sinus sampling: desmopressin vs CRH

Bilateral inferior petrosal sinus sampling (BIPSS) is the gold standard for localizing ACTH-dependent Cushing's syndrome (CS). While corticotropin-releasing hormone (CRH) was initially used for stimulation, desmopressin has become a common alternative. This research evaluates desmopressin'...

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Published in:Hormones (Athens, Greece) Greece), 2024-12
Main Authors: Erkan, Buruc, Cil, Mehmet Said, Cingoz, Mehmet, Burhan, Sebnem, Aksoy, Seyma, Yuzkan, Sabahattin, Akpinar, Ebubekir, Demir, Suat, Tanriverdi, Osman, Kocak, Burak, Cakir, Ilkay, Ciftci, Sema, Ozturk, Feyza Yener, Gunaldi, Omur, Altuntas, Yuksel, Niyazioglu, Mutlu, Hatipoglu, Esra Suheda
Format: Article
Language:English
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Summary:Bilateral inferior petrosal sinus sampling (BIPSS) is the gold standard for localizing ACTH-dependent Cushing's syndrome (CS). While corticotropin-releasing hormone (CRH) was initially used for stimulation, desmopressin has become a common alternative. This research evaluates desmopressin's effectiveness in lateralizing Cushing's disease (CD) during BIPSS compared to CRH stimulation. The study included 33 individuals with ACTH-dependent CS who underwent BIPSS and had diagnoses confirmed by endoscopic endonasal transsphenoidal pituitary surgery (EETPS). Fourteen participants underwent BIPSS with CRH and 19 with desmopressin. A comparative analysis was conducted. BIPSS accurately lateralized 76% of cases, specifically, 71% with CRH and 79% with desmopressin (p = 0.2). For tumors 
ISSN:2520-8721
2520-8721
DOI:10.1007/s42000-024-00620-4