Selective IgM deficiency: evaluation of 75 patients according to different diagnostic criteria

Selective IgM deficiency (SIgMD) has recently been included in the inborn errors of immunity classification. SIgMD has conflicting diagnostic criteria and diverse clinical and immunological findings. We aimed to assess the clinical and laboratory profiles of patients with SIgMD and to compare the da...

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Bibliographic Details
Published in:Immunologic research 2024-12, Vol.73 (1), p.15
Main Authors: Batista, Caroline Hamati Rosa, Smanio, Maria Carolina Martins, Poltronieri, Pedro Borghesi, Resende, Leticia Leme, Kokron, Cristina Maria, Barros, Myrthes Toledo, Agondi, Rosana Camara, Ferraroni, Natasha R., Roxo-Junior, Pérsio, Ferriani, Mariana Paes Leme, Chong-Neto, Herberto, Rosario Filho, Nelson, Kamoi, Tsukiyo Obu, Di Gesu, Regina, Goudouris, Ekaterini, Aranda, Carolina Sanchez, Mansour, Eli, Henriques, Marina T., Bardou, Maine L. D., Antila, Heinrikki G., Grumach, Anete Sevciovic
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age
Aged
Allergic rhinitis
Allergology
Autoimmunity
Biomedical and Life Sciences
Biomedicine
Child
Common variable immunodeficiency
Female
Humans
Immunoglobulin M
Immunoglobulin M - blood
Immunologic Deficiency Syndromes - diagnosis
Immunologic Deficiency Syndromes - immunology
Immunological diseases
Immunology
Internal Medicine
Male
Medicine/Public Health
Middle Aged
Retrospective Studies
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Summary:Selective IgM deficiency (SIgMD) has recently been included in the inborn errors of immunity classification. SIgMD has conflicting diagnostic criteria and diverse clinical and immunological findings. We aimed to assess the clinical and laboratory profiles of patients with SIgMD and to compare the data of patients diagnosed using two inclusion criteria. This was a descriptive, retrospective, observational, collaborative study. Patients were included according to the following definitions: Group 1, IgM levels 
ISSN:0257-277X
1559-0755
1559-0755
DOI:10.1007/s12026-024-09568-4