Long-term risk and characteristics of cerebrovascular events after upper body radiotherapy among childhood cancer survivors in the DCCSS-LATER cohort

• Published in: International journal of cancer 2024-12
• Main Authors: Verbruggen, Lisanne C, Kok, Judith L, Kremer, Leontien C M, Janssens, Geert O, Nederkoorn, Paul J, Penson, Adriaan, Versluijs, A Birgitta, de Vries, Andrica C H, Reedijk, Ardine M J, Bresters, Dorine, Hoving, Eelco W, van Dulmen-den Broeder, Eline, Loonen, Jacqueline J, de Bont, Judith, Wilbers, Joyce, Louwerens, Marloes, van der Heiden-van der Loo, Margriet, van den Heuvel-Eibrink, Marry M, Pluijm, Saskia M F, Neggers, Sebastian J C M M, Tissing, Wim J E, Roos, Yvo B W E M, Ronckers, Cécile M, Teepen, Jop C, van der Pal, Helena J H
• Format: Article
• Language: English
• ISSN: 1097-0215; 1097-0215
• DOI: 10.1002/ijc.35275

Cerebrovascular events (CVEs) are serious late adverse events among childhood cancer survivors. We estimated the incidence and risk factors of symptomatic CVEs and described the clinical characteristics among childhood cancer survivors after upper body radiotherapy. The Dutch Childhood Cancer Survivor Study LATER cohort study includes 5-year childhood cancer survivors diagnosed 50 Gy was associated with 6-fold increased risk, compared to upper body radiotherapy not involving the cranium (hazard ratio = 6.3, 95%CI: 3.3-12.1). In a subgroup with available data on lifestyle and comorbidities, hypertension (odds ratio[OR] = 6.2, 95%CI: 1.6-23.8) and obesity (BMI≥30 vs.