Functions of TAM Receptors and Ligands Protein S and Gas6 in Atherosclerosis and Cardiovascular Disease

Atherosclerosis and cardiovascular disease are associated with high morbidity and mortality in industrialized nations. The Tyro3, Axl, and Mer (TAM) family of receptor tyrosine kinases is involved in the amplification or resolution of atherosclerosis pathology and other cardiovascular pathology. The...

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Bibliographic Details
Published in:International journal of molecular sciences 2024-12, Vol.25 (23), p.12736
Main Authors: Prouse, Teagan, Majumder, Samarpan, Majumder, Rinku
Format: Article
Language:English
Subjects:
Animals
Atherosclerosis
Atherosclerosis - metabolism
Axl Receptor Tyrosine Kinase
B cells
Blood vessels
c-Mer Tyrosine Kinase - metabolism
Cardiovascular diseases
Cardiovascular Diseases - metabolism
Cytokines
Development and progression
Heart attack
Humans
Immune system
Inflammation
Inflammation - metabolism
Intercellular Signaling Peptides and Proteins - metabolism
Kinases
Ligands
Lipids
Medical research
Medicine, Experimental
Mortality
Plasma
Protein S - metabolism
Proteins
Proto-Oncogene Proteins - metabolism
Receptor Protein-Tyrosine Kinases - metabolism
Smooth muscle
Tyrosine
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Summary:Atherosclerosis and cardiovascular disease are associated with high morbidity and mortality in industrialized nations. The Tyro3, Axl, and Mer (TAM) family of receptor tyrosine kinases is involved in the amplification or resolution of atherosclerosis pathology and other cardiovascular pathology. The ligands of these receptors, Protein S (PS) and growth arrest specific protein 6 (Gas6), are essential for TAM receptor functions in the amplification and resolution of atherosclerosis. The Axl-Gas6 interaction has various effects on cardiovascular disease. Mer and PS dampen inflammation, thereby protecting against atherosclerosis progression. Tyro3, the least studied TAM receptor in cardiovascular disease, appears to protect against fibrosis in post-myocardial infarction injury. Ultimately, PS, Gas6, and TAM receptors present an exciting avenue of potential therapeutic targets against inflammation associated with atherosclerosis and cardiovascular disease.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms252312736