Fusarium sacchari CFEM Proteins Suppress Host Immunity and Differentially Contribute to Virulence

The pathogen is responsible for the devastating pokkah boeng disease, which causes significant economic losses in sugarcane production. However, the mechanisms by which it affects plant immunity remain largely unknown. Common in Fungal Extracellular Membrane (CFEM) domain proteins have been implicat...

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Bibliographic Details
Published in:International journal of molecular sciences 2024-12, Vol.25 (23), p.12805
Main Authors: Hong, Tianshu, Wang, Shichao, Luo, Zhiyuan, Ren, Qianqian, Wu, Deng, Wang, Lulu, Bao, Yixue, Yao, Wei, Zhang, Muqing, Hu, Qin
Format: Article
Language:English
Subjects:
Amino acids
Analysis
Binding sites
Cell death
Fungal Proteins - chemistry
Fungal Proteins - genetics
Fungal Proteins - metabolism
Fusarium - pathogenicity
Genomes
Health aspects
Host-Pathogen Interactions - immunology
Immune response
Iron - metabolism
Membrane Proteins - metabolism
Pathogens
Peptides
Plant Diseases - immunology
Plant Diseases - microbiology
Plant Immunity
Plant resistance
Proteins
Saccharum - microbiology
Sugarcane
Virulence
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Summary:The pathogen is responsible for the devastating pokkah boeng disease, which causes significant economic losses in sugarcane production. However, the mechanisms by which it affects plant immunity remain largely unknown. Common in Fungal Extracellular Membrane (CFEM) domain proteins have been implicated in fungal growth, infection processes, and pathogenicity. In this study, we identified three FsCFEM proteins (Fs08184, Fs10706, and Fs13617) that mediate the broad-spectrum suppression of the immune responses induced by typical effectors. A further analysis demonstrated that Fs08184, Fs10706, and Fs13617 suppressed host immunity through two potential iron-binding sites conserved in CFEM family members, characterized by Asp and Phe residues in Fs08184, Fs10706, and Fs13617. Additionally, the Asp and Phe residues within the iron-chelating site were necessary for the iron acquisition of and contributed to creating low-free-iron conditions at the interface of plant and pathogen interactions. It appeared that might employ Asp-Phe-type CFEM members to influence host iron homeostasis to suppress host immunity and to facilitate its successful colonization.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms252312805