Targeting Cancer: A New Era in Cancer Therapy through Immune Fitness Modulation and KRAS Degradation

The rapid advances in cancer research have led to novel therapeutic approaches focusing on previously undruggable targets and immune evasion mechanisms. Recent innovations exemplify these cutting-edge strategies, particularly in KRAS-targeting therapies using PROTAC technology and immune modulation...

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Bibliographic Details
Published in:ACS medicinal chemistry letters 2024-12, Vol.15 (12), p.2074-2076
Main Author: Kargbo, Robert B.
Format: Article
Language:English
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Summary:The rapid advances in cancer research have led to novel therapeutic approaches focusing on previously undruggable targets and immune evasion mechanisms. Recent innovations exemplify these cutting-edge strategies, particularly in KRAS-targeting therapies using PROTAC technology and immune modulation to address resistance in cancer cells. These developments present promising methods for degrading oncogenic proteins and enhancing immune system responses, potentially transforming the cancer treatment landscape. This Patent Highlight showcases these breakthroughs, emphasizing their significant potential to transform cancer therapy.
ISSN:1948-5875
1948-5875
DOI:10.1021/acsmedchemlett.4c00518