Clinical features of taste disorders in Cronkhite-Canada syndrome: A report of 10 cases

Cronkhite-Canada syndrome (CCS) is a very rare gastrointestinal disorder with ectodermal abnormalities. Taste abnormalities appear in more than 80% of cases. Our objective was to investigate the characteristics of CCS. Ten patients with taste abnormalities who were diagnosed with CCS were included....

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Bibliographic Details
Published in:Chemical senses 2024-12
Main Authors: Nin, Tomomi, Kamikozuru, Koji, Takagawa, Tetsuya, Shinzaki, Shinichiro, Tsuzuki, Kenzo
Format: Article
Language:English
Online Access:Get full text
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Summary:Cronkhite-Canada syndrome (CCS) is a very rare gastrointestinal disorder with ectodermal abnormalities. Taste abnormalities appear in more than 80% of cases. Our objective was to investigate the characteristics of CCS. Ten patients with taste abnormalities who were diagnosed with CCS were included. A medical interview, examination of the tongue findings, and blood tests were performed, and taste functions were assessed using an electrogustometry (EGM) and a filter paper disc (FPD) before and after treatment. There were nail atrophy in all cases, weight loss in 8 cases, hair loss in 6 cases, skin hyperpigmentation in 5 cases, gastrointestinal symptoms in 4 cases, and atrophy of the lingual papillae in at least 8 cases. Zinc therapy for taste disorder by the previous physicians was ineffective in all cases. The results of the FPD at the first examination showed a severe decrease in taste function of the anterior tongue, whereas taste function tended to be preserved in the posterior tongue (p
ISSN:0379-864X
1464-3553
1464-3553
DOI:10.1093/chemse/bjae044