Heterogeneity in response to neoadjuvant radiotherapy between soft tissue sarcoma histotypes: associations between radiology and pathology findings

To investigate imaging biomarkers of tumour response by describing changes in imaging and pathology findings after neoadjuvant radiotherapy (nRT) and exploring their correlations. Tumour diameter, volume, and tumour-to-muscle signal intensity (SI) ratio were collected before and after radiotherapy i...

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Published in:European radiology 2024-12
Main Authors: Gennaro, Nicolò, van der Loo, Iris, Reijers, Sophie J M, van Boven, Hester, Snaebjornsson, Petur, Bekers, Elise M, Bodalal, Zuhir, Trebeschi, Stefano, Schrage, Yvonne M, van der Graaf, Winette T A, van Houdt, Winan J, Haas, Rick L M, Velichko, Yury S, Beets-Tan, Regina G H, Bruining, Annemarie
Format: Article
Language:English
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Summary:To investigate imaging biomarkers of tumour response by describing changes in imaging and pathology findings after neoadjuvant radiotherapy (nRT) and exploring their correlations. Tumour diameter, volume, and tumour-to-muscle signal intensity (SI) ratio were collected before and after radiotherapy in a cohort of 107 patients with intermediate/high-grade STS and were correlated with post-radiotherapy pathology findings (percentage of necrosis, viable cells, and fibrosis) using Spearman Rank test. Pathological complete response (pCR) was defined as no residual viable cells present, whereas the presence of
ISSN:1432-1084
1432-1084
DOI:10.1007/s00330-024-11258-6