The Turkish validity and reliability of Addenbrooke's Cognitive Examination III

• Published in: International journal of language & communication disorders 2025-01, Vol.60 (1), p.e13147
• Main Authors: Parlak, Mümüne Merve, Bizpınar Munis, Özlem, Köse, Ayşen, Yıldırım, Cansu, Ülker, Cemil Arcan
• Format: Article
• Language: English
• Subjects: Aged; Aged, 80 and over; Alzheimer Disease - diagnosis; Alzheimer Disease - psychology; Cognition Disorders - diagnosis; Cognition Disorders - psychology; Cognitive Dysfunction - diagnosis; Cognitive Dysfunction - psychology; Dementia - diagnosis; Dementia - psychology; Female; Frontotemporal Dementia - diagnosis; Frontotemporal Dementia - psychology; Humans; Male; Mental Status and Dementia Tests - standards; Middle Aged; Neuropsychological Tests - standards; Psychometrics; Reproducibility of Results; Sensitivity and Specificity; Translating; Translations; Turkey
• ISSN: 1460-6984; 1460-6984
• DOI: 10.1111/1460-6984.13147

Addenbrooke's Cognitive Examination III (ACE-III) was developed as a screening tool for cognitive disorders. Many countries have proven the cultural adaptation, reliability and validity of ACE-III. To make cultural adaptations of ACE-III for the Turkish population and to examine its validity and reliability. First, ACE-III was translated and adapted into Turkish (ACE-III-TR), then its validity and reliability were examined. The study included 234 people: 93 with dementia (78 Alzheimer's disease (AD) and 15 frontotemporal dementia (FTD)), 46 with mild cognitive impairment (MCI) and 95 healthy. Two blinded speech and language therapists rated the ACE-III-TR simultaneously for interrater validity. The same practitioner retested the same participants 2 weeks later for test-retest reliability. The construct validity of the culturally adapted test was assessed by analysing subsection correlations with the ACE-III-TR total score. The association between the Mini-Mental State Examination (MMSE) total score, relevant subsections and ACE-III-TR total score was examined for criterion validity. Intergroup differences for healthy, MCI and dementia were studied for ACE-III-TR subsections and total score, and cut-off scores were calculated for total score with sensitivity and specificity in differential diagnosis. Attention, memory and ACE-III-TR total scores showed a statistically significant difference between the three groups of dementia, MCI and healthy (p