Noninvasive detection of twin zygosity using genome-wide linkage disequilibrium information

Dear Editor, in this study, we propose a novel linkage disequilibrium information-based noninvasive zygosity (LDNZ) assessment method in twin pregnancies. It combines fetus-specific allele frequency analysis with LD block to reduce the number of required single nucleotide polymorphism markers and ex...

Full description

Saved in:
Bibliographic Details
Published in:Clinical and translational medicine 2024-12, Vol.14 (12), p.e70130
Main Authors: Kong, Lingrong, Yang, Yingjun, Yuan, Chao, Wei, Xing, Zhou, Xinyao, Zhou, Jia, Xing, Ya, Zou, Gang, Sun, Qianqian, Cai, Luyao, Liang, Qiufeng, Zhang, Yao, Wang, Hongkun, Liu, Zesi, Wu, Di, Sun, Luming
Format: Article
Language:English
Subjects:
Female
Humans
Linkage Disequilibrium - genetics
Polymorphism, Single Nucleotide - genetics
Pregnancy
Twins, Monozygotic - genetics
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Dear Editor, in this study, we propose a novel linkage disequilibrium information-based noninvasive zygosity (LDNZ) assessment method in twin pregnancies. It combines fetus-specific allele frequency analysis with LD block to reduce the number of required single nucleotide polymorphism markers and experiment costs. LDNZ method offers a noninvasive, accurate, and cost-effective solution for zygosity assessment, addressing the need for precise obstetric care in twin pregnancies.
ISSN:2001-1326
2001-1326
DOI:10.1002/ctm2.70130