Primary Systemic Amyloidosis Characterized by Multiple Keratinous Cysts: A Case Report

A 67-year-old male presented with plaques around the orbit and ecchymosis on the neck and back of hands for 2 years. Physical examination showed seborrheic-keratosis-like plaques around the orbit, ecchymosis on the neck and back of hands, as well as nail dystrophy. Serum λ light chain was positive....

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Bibliographic Details
Published in:Journal of cutaneous pathology 2024-12
Main Authors: Lu, Xiaoou, Fu, Weiwei, Xie, Demin, Li, Fengjuan, Zhang, Jiali, Wang, Da, Sun, Yu, Chen, Hongquan
Format: Article
Language:English
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Summary:A 67-year-old male presented with plaques around the orbit and ecchymosis on the neck and back of hands for 2 years. Physical examination showed seborrheic-keratosis-like plaques around the orbit, ecchymosis on the neck and back of hands, as well as nail dystrophy. Serum λ light chain was positive. Histopathological examination demonstrated multiple keratinous cysts in the dermis and eosinophilic homogeneous material in the dermis, which was positive for Congo red with apple-green birefringence on polarized light. Kidney biopsy showed deposition of acellular eosinophilic material in the arteriole wall. Congo red staining was positive. A bone marrow biopsy revealed multiple myeloma. The diagnosis of primary systemic amyloidosis with multiple myeloma was made.
ISSN:0303-6987
1600-0560
1600-0560
DOI:10.1111/cup.14763