Can ferroptosis be a target for reproductive health?

Ferroptosis has been implicated in several reproductive disorders, but the underlying mechanisms remain unknown; thus, interventions targeting this pathway are lacking. Here we summarize the emerging findings on ferroptosis in reproductive biology and corresponding disorders, and highlight perspecti...

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Bibliographic Details
Published in:Trends in endocrinology and metabolism 2024-12
Main Authors: Hu, Mengchun, Qin, Yingying, Jiao, Xue
Format: Article
Language:English
Subjects:
challenges
ferroptosis
opportunities
reproductive disorders
reproductive health
Online Access:Get full text
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Summary:Ferroptosis has been implicated in several reproductive disorders, but the underlying mechanisms remain unknown; thus, interventions targeting this pathway are lacking. Here we summarize the emerging findings on ferroptosis in reproductive biology and corresponding disorders, and highlight perspectives and challenges on future ferroptosis research with potential clinical applications. Ferroptosis has been implicated in several reproductive disorders, but the underlying mechanisms remain unknown; thus, interventions targeting this pathway are lacking. Here we summarize the emerging findings on ferroptosis in reproductive biology and corresponding disorders, and highlight perspectives and challenges on future ferroptosis research with potential clinical applications.
ISSN:1043-2760
1879-3061
1879-3061
DOI:10.1016/j.tem.2024.11.011