Neuroprotective effect of red dragon fruit extract ameliorates oxidative stress and inflammation in D-galactose-induced aging rat model: biochemical, histological and immunohistochemical study

Aging is a worldwide socioeconomic burden. Cerebellar aging is an enigma contributing to many behavioral aging disorders, hence is its hindering by prophylactic measurements is a crucial geriatric research target. Red dragon fruit (RDF) is a tropical fruit with antioxidant, anti-inflammatory and ant...

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Published in:Journal of molecular histology 2025-02, Vol.56 (1), p.51
Main Authors: Ibrahim, Manar Fouli Gaber, Ali, Fatma F., Ali, Sayed Fouad El-Sheikh, Shaker, Emad S., Mahmoud, Hemdan I., Abdellatif, Fatma ElZahraa Mohammed, Mokhemer, Sahar A.
Format: Article
Language:English
Subjects:
Aging
Antioxidants
Apoptosis
Biochemical analysis
Biomedical and Life Sciences
Biomedicine
Caspase-3
Cell Biology
Cerebellum
D-Galactose
Developmental Biology
Endothelium
Fruits
Galactose
Immunohistochemistry
Inflammation
Life Sciences
Myelination
Neuroprotection
Nitric-oxide synthase
Original Paper
Oxidative stress
Purkinje cells
Tumor necrosis factor-α
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Summary:Aging is a worldwide socioeconomic burden. Cerebellar aging is an enigma contributing to many behavioral aging disorders, hence is its hindering by prophylactic measurements is a crucial geriatric research target. Red dragon fruit (RDF) is a tropical fruit with antioxidant, anti-inflammatory and anti-apoptotic properties. This study aimed to determine the protective effect of RDF extract against cerebellar aging. Thirty-two male albino rats were randomly allocated into 4 groups: Control, RDF, aged and RDF-aged groups. Aged group revealed structural distortion affecting cerebellar layers including a significant (P 
ISSN:1567-2379
1567-2387
1567-2387
DOI:10.1007/s10735-024-10316-z