Exploration of plasma tryptophan levels along with Ki-67 expression binomial investigation for forecasting tumor aggressiveness within invasive ductal breast cancer

• Published in: Journal of molecular histology 2024-12, Vol.56 (1), p.52
• Main Authors: Salmi, Takwa, Ameur, Djilali, Dali-Sahi, Majda, Dib, Joanna, Amraoui, Nawel, Kachekouche, Youssouf, Dennouni-Medjati, Nouria
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor - blood; Biomedical and Life Sciences; Biomedicine; Breast cancer; Breast carcinoma; Breast Neoplasms - blood; Breast Neoplasms - diagnosis; Breast Neoplasms - pathology; Carcinoma, Ductal, Breast - blood; Carcinoma, Ductal, Breast - diagnosis; Carcinoma, Ductal, Breast - metabolism; Carcinoma, Ductal, Breast - pathology; Cell Biology; Developmental Biology; Female; Humans; Immune response; Invasiveness; Ki-67 Antigen - analysis; Ki-67 Antigen - blood; Ki-67 Antigen - metabolism; Life Sciences; Middle Aged; Mitotic Index; Original Paper; Plasma; Plasma levels; Population studies; Prediction models; Prognosis; Regression analysis; Risk factors; Statistical analysis; Statistical models; Tryptophan; Tryptophan - blood; Tryptophan - metabolism; Tumors
• ISSN: 1567-2379; 1567-2387; 1567-2387
• DOI: 10.1007/s10735-024-10333-y

Ki-67 is a histological marker indicating cancer aggressiveness, while tryptophan (TRP) depletion modulates immune responses, including tumor aggressiveness. The study evaluates Ki-67's predictive value in relation to plasma TRP levels in invasive ductal carcinoma of breast cancer, aiming to improve understanding of tumor characteristics and clinical behavior. A study involving 165 women, measured plasma TRP levels and Ki-67 and analyzed their relationship with tumor aggressiveness markers using statistical analyses and predictive models. Our study highlighted a significant correlation between decreased plasma levels of TRP and a high mitotic index, measured by the Ki-67 marker (Pearson correlation coefficient r = − 0.402; p = 0.011). Tryptophan levels below 40 µmol/L were associated with a Ki-67 level above 15%, suggesting more active tumor growth in patients. Additionally, several risk factors for BC were identified within the studied population. The demographic and clinical characteristics of the participants include an average age of 63 years, plasma glucose levels above 1.2 g/L, and plasma TRP levels below 40 µmol/L, which are associated with an increased risk of BC. Furthermore, various polynomial logistic regression models indicate that TRP levels may be predicted based on Ki-67 expression, providing a promising approach to refine prognostic assessments. The study showed a correlation between low levels of tryptophan (TRP) and a high Ki-67 mitotic index in breast cancer patients, particularly in invasive ductal carcinoma, which is strongly linked to the aggressiveness of the disease. The integration of these markers into routine practice remains a technical and economic challenge.