Gender differences in the association between insulin resistance assessed by estimated glucose disposal rate and the risk of all-cause and cardiovascular deaths in adults without diabetes

• Published in: Diabetes research and clinical practice 2025-01, Vol.219, p.111966, Article 111966
• Main Authors: Wang, Haixu, Zhou, Zeming, Liu, Xiaoxin, Chen, Ying
• Format: Article
• Language: English
• Subjects: Death; eGDR; Gender; Non-diabetic; Risk
• ISSN: 0168-8227; 1872-8227; 1872-8227
• DOI: 10.1016/j.diabres.2024.111966

We intended to examine the relationship between estimated glucose disposal rate (eGDR) and risks of all-cause and cardiovascular deaths in non-diabetic adults. 38,175 participants from the National Health and Nutrition Examination Survey (1999–2018) were included, and deaths were identified through the National Death Index. With a median follow-up of 9.8 years, we found that dose–response relationships between eGDR level and the risk of death differed between genders. In female participants, higher eGDR level was linearly correlated with lower risks of all-cause and cardiovascular deaths. In contrast, among male participants, there were L-shaped relationships between eGDR and risks of all-cause and cardiovascular deaths, with threshold points of 8.50 and 8.49 mg/kg/min, respectively. To the left of threshold points, eGDR was negatively linked with risks of all-cause (HR 0.91, 95 % CI 0.88–0.94, P