Radiological Sublingual Space Invasion in Tongue Squamous Cell Carcinoma: Clinicopathological Associations and Impact on Survival

We investigate if sublingual space invasion (SLI) determined on magnetic resonance imaging confers differences in clinicopathological manifestations and treatment outcomes of oral tongue squamous cell carcinoma (OTSCC). Retrospective cohort study. Tertiary Academic Medical Center. 221 OTSCC patients...

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Published in:Otolaryngology-head and neck surgery 2024-12
Main Authors: See, Anna, Yang, Min-Cun, Huang, Yenlin, Tsai, Tsung-You, Lee, Chi-Yin, Huang, Pin-Hsuan, Tseng, Ti-Yung, Ng, Shu-Hang, Chang, Kai-Ping
Format: Article
Language:English
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Summary:We investigate if sublingual space invasion (SLI) determined on magnetic resonance imaging confers differences in clinicopathological manifestations and treatment outcomes of oral tongue squamous cell carcinoma (OTSCC). Retrospective cohort study. Tertiary Academic Medical Center. 221 OTSCC patients were included. Cox regression models and Kaplan-Meier methods were used, and nomogram construction was performed, incorporating SLI with other adverse factors, to predict the prognosis. On multivariable analysis, the following were associated with cervical nodal metastasis: (1) greater MRI T classification of T3/T4 versus T1/T2: adjusted odds ratio (aOR) 2.784, 95% CI = 1.459 to 5.313, P = .001; (2) gender (female vs male): aOR 4.117, 95% CI = 1.602 to 10.576, P = .003; (3) presence of MRI-determined SLI: aOR 2.588, 95% CI = 1.393 to 4.808, P = .002. For survival outcomes, extranodal extension (adjusted hazard ratio [aHR]: 3.380, 95% CI = 2.024-5.644, P 
ISSN:1097-6817
1097-6817
DOI:10.1002/ohn.1097