Protective effects of Sulforaphene on kidney damage and gut dysbiosis in high-fat diet plus streptozotocin-induced diabetic mice

Diabetic nephropathy (DN) is one of the most serious and prevalent complications associated with diabetes. Consequently, antidiabetic drugs or foods potentially protecting the kidneys are of significant therapeutic value. Sulforaphene (SFE) is a natural isothiocyanate derived from radish seeds, know...

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Bibliographic Details
Published in:Food chemistry 2024-12, Vol.469, p.142558, Article 142558
Main Authors: Zhang, Bo, Xu, Kang, Deng, Wenlei, Liu, Ce, Xu, Qianmin, Sheng, Huakang, Feng, Jialu, Yuan, Qipeng
Format: Article
Language:English
Subjects:
Gut microbiota
Inflammation
Kidney protective effects
Oxidative stress
Streptozotocin
Sulforaphene
Online Access:Get full text
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Summary:Diabetic nephropathy (DN) is one of the most serious and prevalent complications associated with diabetes. Consequently, antidiabetic drugs or foods potentially protecting the kidneys are of significant therapeutic value. Sulforaphene (SFE) is a natural isothiocyanate derived from radish seeds, known for its anti-inflammatory and antioxidant properties. However, no studies have investigated on the ability of SFE to prevent or treat DN. This study established a high-fat diet combined with a streptozotocin-induced type II diabetes mellitus mouse model. We administered SFE treatment to examine its protective effects on renal and intestinal homeostasis in DN mice. After 4 weeks of treatment, SFE (50 mg/kg b.w.) not only reduced blood glucose concentration (20.3 %, P 
ISSN:0308-8146
1873-7072
1873-7072
DOI:10.1016/j.foodchem.2024.142558