Oxidative stress profile and auto-antibodies production in Tunisian patients with COVID-19

The clinical evidence, complications and the pathogenesis of COVID-19 are not clearly understood. In COVID-19 patients, cellular immune response biomarkers and oxidative stress parameters have been used as gravity markers. Indeed, oxidative stress has been proposed to play an essential role in the g...

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Bibliographic Details
Published in:Cytotechnology (Dordrecht) 2025-02, Vol.77 (1), p.22
Main Authors: Gargouri, Bochra, Amor, Ichrak Ben, Ramma, Yosra, Mansour, Riad Ben, Bayoudh, Ahmed, Kallel, Imen, Attia, Hammadi
Format: Article
Language:English
Subjects:
Antibodies
Antigens
Antioxidants
Autoantibodies
Autoimmune diseases
Biochemistry
Biomedicine
Biotechnology
Chemistry
Chemistry and Materials Science
Coronaviruses
COVID-19
Disease
Enzyme-linked immunosorbent assay
Enzymes
Hepatitis
Immune response
Immune response (cell-mediated)
Immunoglobulin G
Immunoglobulin M
Isotypes
Lipid peroxidation
Lipids
Lupus
Malondialdehyde
Oxidation
Oxidative stress
Pandemics
Pathogenesis
Patients
Proteins
Signal transduction
Statistical analysis
Superoxide dismutase
Variance analysis
Viral infections
Viruses
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Summary:The clinical evidence, complications and the pathogenesis of COVID-19 are not clearly understood. In COVID-19 patients, cellular immune response biomarkers and oxidative stress parameters have been used as gravity markers. Indeed, oxidative stress has been proposed to play an essential role in the genesis of COVID-19. In the present research, we investigated lipid peroxidation, protein oxidation, superoxide dismutase activity and the production of auto-antibodies against superoxide dismutase, in the blood of Tunisian patients with corona virus. To evaluate lipid peroxidation, plasma malondialdehyde and conjugated dienes, have been determined in 69 corona virus patients and 30 controls. To determine protein oxidation the thiol level was measured. Plasma superoxide dismutase activity has been measured in 30 corona virus patients and 30 controls on one hand. Utilizing a standard enzyme-linked immunosorbent assay, the level of immunoglobulin G (IgG), and M (IgM) directed against superoxide dismutase was evaluated. To investigate the implication of auto-antibody production in COVID-19 patients in the generation of oxidative stress, a correlation study between auto-antibodies production and oxidative stress parameters was performed. High levels of both malondialdehyde and conjugated dienes were found in the plasma of patients (p 
ISSN:0920-9069
1573-0778
DOI:10.1007/s10616-024-00683-6