Plant Endophytic fungi: Powerful catalytic cells for biotransformation of chemical structures of biologically active compounds

• Published in: Chemistry & biodiversity 2024-12, p.e202402281
• Main Authors: Palupi, Kartika Dyah, Oktavia, Listiana, Wulansari, Dewi, Rahmi, Dwinna, Fathoni, Ahmad, Agusta, Andria
• Format: Article
• Language: English
• ISSN: 1612-1880; 1612-1880
• DOI: 10.1002/cbdv.202402281

Fungal endophytes are recognized as an essential source of bioactive compounds. Besides producing a wide variety of compounds, fungal endophytes can also facilitate a biotransformation process. In this process, endophytes act as an enzyme source to catalyze chemical reactions and modify the structures of bioactive compounds. Biotransformation offers advantages over chemical synthesis, for instance, the allowance of eco-friendly reactions and regio-selective as well as a stereo-selective synthesis that is often difficult to achieve using chemical synthesis. This review focuses on the utilization of endophytic fungi in the biotransformation process of bioactive compounds to improve their pharmacological, pharmacokinetic, or toxicological parameters. We also discuss the future perspectives and obstacles of using the endophytic fungi-based biotransformation process on an industrial scale.