The "Mammograms Available Due to Resources and Education" (MADRE) Study: Rationale and Design

• Published in: Contemporary clinical trials 2024-12, p.107786
• Main Authors: McClellan, Sean P, De La Paz, Elizabeth, Arroyo, Juanita, Montoya, Silvia, Perez, Jocelyn, Wright, Ezra, Moreno, Emely, Padilla, Monica, Kroenke, Candyce H, Rauscher, Garth H, Neuschler, Erin, Ganschow, Pamela, Stackhouse, Nathan, Atkins, Marc, Dziak, John J, Neal, Jennifer Watling, Lucio, Araceli, Molina, Yamile
• Format: Article
• Language: English
• ISSN: 1559-2030; 1559-2030
• DOI: 10.1016/j.cct.2024.107786

Latinas suffer disproportionately from breast cancer, partially due to lower uptake of guideline-concordant breast cancer screening. We describe the design of a study to compare two approaches addressing this important public health problem. We are conducting a 5-year randomized controlled trial. From a federally qualified health center network and through community outreach, we are recruiting 400 Latinas from Chicago who are non-adherent with United States Preventive Services Task Force breast cancer screening guidelines. Participants are randomized at a 1:1 ratio to receive one of two phone-based interventions (empowerment, education) administered across 3 weekly sessions. Both interventions provide information about breast cancer early detection. The empowerment intervention additionally teaches participants to share information about breast cancer screening with family and friends, while the education intervention educates patients about breast cancer prevention. Non-adherent Latina participants recruit family and friends eligible for breast cancer screening to take part in the study as network members. Network members do not participate in the intervention. Primary outcomes are initial (any mammogram post-enrollment) and repeat (measured at two-year intervals after enrollment) breast cancer screening among intervention participants and network members. Additionally, we will use multi-level structural equation models to assess potential mediators of the impact of the interventions. This study will inform the development of empowerment approaches to increase participation in breast cancers screening among Latinas and reduce health disparities. NCT05841355.