Cleome arabica L mitigates bisphenol A-induced ovarian dysfunction and inflammation in Wistar rats: biochemical, histopathological, pharmacokinetic, and in silico studies

The present study evaluated the antioxidant and anti-inflammatory properties of Cleome arabica (CA) fruit extract against bisphenol A (BPA)-induced ovarian injury in female Wistar rats. The antioxidant activity was estimated by the total antioxidant capacity (TAC) and superoxide radical (NBT) conten...

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Bibliographic Details
Published in:3 Biotech 2025, Vol.15 (1), p.21
Main Authors: Allagui, Ikram, Sdayria, Jazia, Athmouni, Khaled, Zammel, Nourhene, Guesmi, Fatma, Saoudi, Mongi, Giuffrè, Angelo Maria, Allagui, Mohamed Salah, Nahdi, Saber, Harrath, Abdel Halim
Format: Article
Language:English
Subjects:
Agriculture
Anti-inflammatory agents
Antioxidants
Bioinformatics
Biomaterials
Biotechnology
Bisphenol A
Body weight
C-reactive protein
Cancer Research
Catechin
Chemical bonds
Chemistry
Chemistry and Materials Science
Cleome
Females
IL-1β
Infertility
Inflammation
Injury analysis
Interleukin 6
Kaempferol
Naringenin
Original Article
Ovaries
Pharmacokinetics
Polycystic ovary syndrome
Quercetin
Rosmarinic acid
Stem Cells
Testosterone
Tumor necrosis factor-α
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Summary:The present study evaluated the antioxidant and anti-inflammatory properties of Cleome arabica (CA) fruit extract against bisphenol A (BPA)-induced ovarian injury in female Wistar rats. The antioxidant activity was estimated by the total antioxidant capacity (TAC) and superoxide radical (NBT) content. For the in vivo analyses, 24 animals were divided into the following 4 groups: the control group; the BPA group (50 mg/kg BW BPA for 30 days); the BPA  + CA group (50 mg/kg BW BPA and 50 mg/kg BW CA); and the CA group (50 mg/kg BW CA). The in vitro results demonstrated that CA exhibited strong antioxidant activity and scavenged O 2 •− radicals. . Pharmacokinetic properties were also explored, reflecting the physiological dynamics of the five active molecules (quercetin, catechin, kaempferol, rosmarinic acid, and naringenin). The in vivo findings revealed a significant increase in body weight associated with a significant increase in plasma C-reactive protein (CRP), proinflammatory cytokines (IL-1, IL-6, and TNF-α), and testosterone levels ( p  
ISSN:2190-572X
2190-5738
DOI:10.1007/s13205-024-04169-2