CT-Radiomics and Pathological Tumor Response to Systemic Therapy: A Predictive Analysis for Colorectal Liver Metastases. Development and Internal Validation of a Clinical-Radiomic Model

• Published in: European journal of surgical oncology 2024-12, Vol.51 (3), p.109557, Article 109557
• Main Authors: Ammirabile, Angela, Cavinato, Lara, Paolina Ferro, Carola Anna, Fiz, Francesco, Savino, Matteo Stefano, Russolillo, Nadia, Mussetto, Annalisa Balbo, Ragaini, Elisa Maria, Lanza, Ezio, Akpinar, Reha, Procopio, Fabio, Francone, Marco, Terracciano, Luigi Maria, Gallo, Teresa, De Rosa, Giovanni, Ferrero, Alessandro, Di Tommaso, Luca, Ieva, Francesca, Torzilli, Guido, Viganò, Luca
• Format: Article
• Language: English
• Subjects: colorectal liver metastases; computed tomography; neoadjuvant chemotherapy; pathological response; radiomics; tumor regression grade
• ISSN: 0748-7983; 1532-2157; 1532-2157
• DOI: 10.1016/j.ejso.2024.109557

The standard treatment of colorectal liver metastases (CRLM) is surgery with perioperative chemotherapy. A tumor response to systemic therapy confirmed at pathology examination is the strongest predictor of survival, but it cannot be adequately predicted in the preoperative setting. This bi-institutional retrospective study investigates whether CT-based radiomics of CRLM and peritumoral tissue provides a reliable non-invasive estimation of the pathological tumor response to chemotherapy. All consecutive patients undergoing liver resection for CRLM at the two institutions were considered. Only patients with a radiological partial response or stable disease at chemotherapy and with a preoperative/post-chemotherapy CT performed