Metabolic factors modulate effort-based decision-making in major depressive disorder

Abnormalities in effort-based decision-making have been consistently reported in major depressive disorder (MDD). Evidence indicates that metabolic factors, such as insulin resistance and dyslipidemia, which are highly prevalent in MDD, are independently associated with reward disturbances. Herein,...

Full description

Saved in:
Bibliographic Details
Published in:Journal of affective disorders 2024-12, Vol.373, p.88-93
Main Authors: Gill, Hartej, Badulescu, Sebastian, Di Vincenzo, Joshua D., Tabassum, Aniqa, McKenzie, Andrea, Shah, Hiya, Amin, Mahrus, Llach, Cristian-Daniel, Rosenblat, Joshua D., McIntyre, Roger S., Mansur, Rodrigo B.
Format: Article
Language:English
Subjects:
Effort
Glucose
Insulin
Lipids
Major depressive disorder
Reward
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abnormalities in effort-based decision-making have been consistently reported in major depressive disorder (MDD). Evidence indicates that metabolic factors, such as insulin resistance and dyslipidemia, which are highly prevalent in MDD, are independently associated with reward disturbances. Herein, we investigate the moderating effect of metabolic factors on effort-based decision-making in individuals with MDD. Forty-nine adults with MDD completed the Effort Expenditure for Rewards Task (EEfRT). Anthropometric and laboratorial parameters were assessed in all participants. We conducted a factor analysis to identify combinations of correlated metabolic variables, and reduce the number of comparisons. Proxy markers of elevated insulin resistance (OR: 0.816, p 
ISSN:0165-0327
1573-2517
1573-2517
DOI:10.1016/j.jad.2024.12.090