Hyperspectral Metachip-Based 3D Spatial Map for Cancer Cell Screening and Quantification

• Published in: Advanced materials (Weinheim) 2024-12, p.e2412738
• Main Authors: Zhao, Zihan, Tang, Xiaocong, Ji, Chang-Yin, Meng, Yanli, Liang, Xinyue, Luo, Rui, Wang, Cong, Wu, Qun, Liu, Jian, Dang, Cuong, Hu, Guangwei, Ding, Xumin
• Format: Article
• Language: English
• ISSN: 0935-9648; 1521-4095; 1521-4095
• DOI: 10.1002/adma.202412738

In this paper, compact terahertz (THz) metachips for hyperspectral screening and quantitative evaluation of human cancer cells is reported. This pixelated resonant metachips feature the resonance channel from 1 and 3 THz frequency with a record-high quality factor (up to 230). Through the interactions of various cancer cells of different concentrations, high-dimensional spectral signatures are obtained, which are further transformed into a spatial map for labelling and quantification purposes. The screening of up to 15 cancer cells is experimentally reported, with very high detecting accuracy of 93.33% and with attractive quantitative concentration sensitivity up to 1320 kHz cell mL . This hyperspectral metachips are low-cost, highly compact, and label-free for fast, high-throughput and high-sensitivity detections and evaluation of human cancer cells. This technology does not require clinical experience, representing an accessible technology for early diagnosis of cancer.