Hyperspectral Metachip-Based 3D Spatial Map for Cancer Cell Screening and Quantification

In this paper, compact terahertz (THz) metachips for hyperspectral screening and quantitative evaluation of human cancer cells is reported. This pixelated resonant metachips feature the resonance channel from 1 and 3 THz frequency with a record-high quality factor (up to 230). Through the interactio...

Full description

Saved in:
Bibliographic Details
Published in:Advanced materials (Weinheim) 2024-12, p.e2412738
Main Authors: Zhao, Zihan, Tang, Xiaocong, Ji, Chang-Yin, Meng, Yanli, Liang, Xinyue, Luo, Rui, Wang, Cong, Wu, Qun, Liu, Jian, Dang, Cuong, Hu, Guangwei, Ding, Xumin
Format: Article
Language:English
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites cdi_FETCH-LOGICAL-c180t-f78a3174cc1e64cf9fd718107d1fc3ee711e2f83616ca143543df8948a9f01c13
container_end_page
container_issue
container_start_page e2412738
container_title Advanced materials (Weinheim)
container_volume
creator Zhao, Zihan
Tang, Xiaocong
Ji, Chang-Yin
Meng, Yanli
Liang, Xinyue
Luo, Rui
Wang, Cong
Wu, Qun
Liu, Jian
Dang, Cuong
Hu, Guangwei
Ding, Xumin
description In this paper, compact terahertz (THz) metachips for hyperspectral screening and quantitative evaluation of human cancer cells is reported. This pixelated resonant metachips feature the resonance channel from 1 and 3 THz frequency with a record-high quality factor (up to 230). Through the interactions of various cancer cells of different concentrations, high-dimensional spectral signatures are obtained, which are further transformed into a spatial map for labelling and quantification purposes. The screening of up to 15 cancer cells is experimentally reported, with very high detecting accuracy of 93.33% and with attractive quantitative concentration sensitivity up to 1320 kHz cell mL . This hyperspectral metachips are low-cost, highly compact, and label-free for fast, high-throughput and high-sensitivity detections and evaluation of human cancer cells. This technology does not require clinical experience, representing an accessible technology for early diagnosis of cancer.
doi_str_mv 10.1002/adma.202412738
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3150345739</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3150345739</sourcerecordid><originalsourceid>FETCH-LOGICAL-c180t-f78a3174cc1e64cf9fd718107d1fc3ee711e2f83616ca143543df8948a9f01c13</originalsourceid><addsrcrecordid>eNo9kEtPwzAQhC0EoqVw5Yh85JLijZ04PkJ5FKkIoYLELVqcNQTlhZ0c-u9J1cJpRtqZ0epj7BzEHISIr7CocR6LWEGsZXbAppDEEClhkkM2FUYmkUlVNmEnIXwLIUwq0mM2kUZLPdope19uOvKhI9t7rPgT9Wi_yi66wUAFl7d83WFfbi_Ycdd6vsDG0ihUVXxtPVFTNp8cm4K_DNj0pSvtWGibU3bksAp0ttcZe7u_e10so9Xzw-PiehVZyEQfOZ2hBK2sBUqVdcYVGjIQugBnJZEGoNhlMoXUIiiZKFm4zKgMjRNgQc7Y5W638-3PQKHP6zLY8TtsqB1CLiERUiVamjE630Wtb0Pw5PLOlzX6TQ4i39LMtzTzf5pj4WK_PXzUVPzH__DJX9Psb4g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3150345739</pqid></control><display><type>article</type><title>Hyperspectral Metachip-Based 3D Spatial Map for Cancer Cell Screening and Quantification</title><source>Wiley-Blackwell Read &amp; Publish Collection</source><creator>Zhao, Zihan ; Tang, Xiaocong ; Ji, Chang-Yin ; Meng, Yanli ; Liang, Xinyue ; Luo, Rui ; Wang, Cong ; Wu, Qun ; Liu, Jian ; Dang, Cuong ; Hu, Guangwei ; Ding, Xumin</creator><creatorcontrib>Zhao, Zihan ; Tang, Xiaocong ; Ji, Chang-Yin ; Meng, Yanli ; Liang, Xinyue ; Luo, Rui ; Wang, Cong ; Wu, Qun ; Liu, Jian ; Dang, Cuong ; Hu, Guangwei ; Ding, Xumin</creatorcontrib><description>In this paper, compact terahertz (THz) metachips for hyperspectral screening and quantitative evaluation of human cancer cells is reported. This pixelated resonant metachips feature the resonance channel from 1 and 3 THz frequency with a record-high quality factor (up to 230). Through the interactions of various cancer cells of different concentrations, high-dimensional spectral signatures are obtained, which are further transformed into a spatial map for labelling and quantification purposes. The screening of up to 15 cancer cells is experimentally reported, with very high detecting accuracy of 93.33% and with attractive quantitative concentration sensitivity up to 1320 kHz cell mL . This hyperspectral metachips are low-cost, highly compact, and label-free for fast, high-throughput and high-sensitivity detections and evaluation of human cancer cells. This technology does not require clinical experience, representing an accessible technology for early diagnosis of cancer.</description><identifier>ISSN: 0935-9648</identifier><identifier>ISSN: 1521-4095</identifier><identifier>EISSN: 1521-4095</identifier><identifier>DOI: 10.1002/adma.202412738</identifier><identifier>PMID: 39737606</identifier><language>eng</language><publisher>Germany</publisher><ispartof>Advanced materials (Weinheim), 2024-12, p.e2412738</ispartof><rights>2024 Wiley‐VCH GmbH.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c180t-f78a3174cc1e64cf9fd718107d1fc3ee711e2f83616ca143543df8948a9f01c13</cites><orcidid>0000-0002-3023-9632</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39737606$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhao, Zihan</creatorcontrib><creatorcontrib>Tang, Xiaocong</creatorcontrib><creatorcontrib>Ji, Chang-Yin</creatorcontrib><creatorcontrib>Meng, Yanli</creatorcontrib><creatorcontrib>Liang, Xinyue</creatorcontrib><creatorcontrib>Luo, Rui</creatorcontrib><creatorcontrib>Wang, Cong</creatorcontrib><creatorcontrib>Wu, Qun</creatorcontrib><creatorcontrib>Liu, Jian</creatorcontrib><creatorcontrib>Dang, Cuong</creatorcontrib><creatorcontrib>Hu, Guangwei</creatorcontrib><creatorcontrib>Ding, Xumin</creatorcontrib><title>Hyperspectral Metachip-Based 3D Spatial Map for Cancer Cell Screening and Quantification</title><title>Advanced materials (Weinheim)</title><addtitle>Adv Mater</addtitle><description>In this paper, compact terahertz (THz) metachips for hyperspectral screening and quantitative evaluation of human cancer cells is reported. This pixelated resonant metachips feature the resonance channel from 1 and 3 THz frequency with a record-high quality factor (up to 230). Through the interactions of various cancer cells of different concentrations, high-dimensional spectral signatures are obtained, which are further transformed into a spatial map for labelling and quantification purposes. The screening of up to 15 cancer cells is experimentally reported, with very high detecting accuracy of 93.33% and with attractive quantitative concentration sensitivity up to 1320 kHz cell mL . This hyperspectral metachips are low-cost, highly compact, and label-free for fast, high-throughput and high-sensitivity detections and evaluation of human cancer cells. This technology does not require clinical experience, representing an accessible technology for early diagnosis of cancer.</description><issn>0935-9648</issn><issn>1521-4095</issn><issn>1521-4095</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNo9kEtPwzAQhC0EoqVw5Yh85JLijZ04PkJ5FKkIoYLELVqcNQTlhZ0c-u9J1cJpRtqZ0epj7BzEHISIr7CocR6LWEGsZXbAppDEEClhkkM2FUYmkUlVNmEnIXwLIUwq0mM2kUZLPdope19uOvKhI9t7rPgT9Wi_yi66wUAFl7d83WFfbi_Ycdd6vsDG0ihUVXxtPVFTNp8cm4K_DNj0pSvtWGibU3bksAp0ttcZe7u_e10so9Xzw-PiehVZyEQfOZ2hBK2sBUqVdcYVGjIQugBnJZEGoNhlMoXUIiiZKFm4zKgMjRNgQc7Y5W638-3PQKHP6zLY8TtsqB1CLiERUiVamjE630Wtb0Pw5PLOlzX6TQ4i39LMtzTzf5pj4WK_PXzUVPzH__DJX9Psb4g</recordid><startdate>20241231</startdate><enddate>20241231</enddate><creator>Zhao, Zihan</creator><creator>Tang, Xiaocong</creator><creator>Ji, Chang-Yin</creator><creator>Meng, Yanli</creator><creator>Liang, Xinyue</creator><creator>Luo, Rui</creator><creator>Wang, Cong</creator><creator>Wu, Qun</creator><creator>Liu, Jian</creator><creator>Dang, Cuong</creator><creator>Hu, Guangwei</creator><creator>Ding, Xumin</creator><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3023-9632</orcidid></search><sort><creationdate>20241231</creationdate><title>Hyperspectral Metachip-Based 3D Spatial Map for Cancer Cell Screening and Quantification</title><author>Zhao, Zihan ; Tang, Xiaocong ; Ji, Chang-Yin ; Meng, Yanli ; Liang, Xinyue ; Luo, Rui ; Wang, Cong ; Wu, Qun ; Liu, Jian ; Dang, Cuong ; Hu, Guangwei ; Ding, Xumin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c180t-f78a3174cc1e64cf9fd718107d1fc3ee711e2f83616ca143543df8948a9f01c13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhao, Zihan</creatorcontrib><creatorcontrib>Tang, Xiaocong</creatorcontrib><creatorcontrib>Ji, Chang-Yin</creatorcontrib><creatorcontrib>Meng, Yanli</creatorcontrib><creatorcontrib>Liang, Xinyue</creatorcontrib><creatorcontrib>Luo, Rui</creatorcontrib><creatorcontrib>Wang, Cong</creatorcontrib><creatorcontrib>Wu, Qun</creatorcontrib><creatorcontrib>Liu, Jian</creatorcontrib><creatorcontrib>Dang, Cuong</creatorcontrib><creatorcontrib>Hu, Guangwei</creatorcontrib><creatorcontrib>Ding, Xumin</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Advanced materials (Weinheim)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhao, Zihan</au><au>Tang, Xiaocong</au><au>Ji, Chang-Yin</au><au>Meng, Yanli</au><au>Liang, Xinyue</au><au>Luo, Rui</au><au>Wang, Cong</au><au>Wu, Qun</au><au>Liu, Jian</au><au>Dang, Cuong</au><au>Hu, Guangwei</au><au>Ding, Xumin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hyperspectral Metachip-Based 3D Spatial Map for Cancer Cell Screening and Quantification</atitle><jtitle>Advanced materials (Weinheim)</jtitle><addtitle>Adv Mater</addtitle><date>2024-12-31</date><risdate>2024</risdate><spage>e2412738</spage><pages>e2412738-</pages><issn>0935-9648</issn><issn>1521-4095</issn><eissn>1521-4095</eissn><abstract>In this paper, compact terahertz (THz) metachips for hyperspectral screening and quantitative evaluation of human cancer cells is reported. This pixelated resonant metachips feature the resonance channel from 1 and 3 THz frequency with a record-high quality factor (up to 230). Through the interactions of various cancer cells of different concentrations, high-dimensional spectral signatures are obtained, which are further transformed into a spatial map for labelling and quantification purposes. The screening of up to 15 cancer cells is experimentally reported, with very high detecting accuracy of 93.33% and with attractive quantitative concentration sensitivity up to 1320 kHz cell mL . This hyperspectral metachips are low-cost, highly compact, and label-free for fast, high-throughput and high-sensitivity detections and evaluation of human cancer cells. This technology does not require clinical experience, representing an accessible technology for early diagnosis of cancer.</abstract><cop>Germany</cop><pmid>39737606</pmid><doi>10.1002/adma.202412738</doi><orcidid>https://orcid.org/0000-0002-3023-9632</orcidid></addata></record>
fulltext fulltext
identifier ISSN: 0935-9648
ispartof Advanced materials (Weinheim), 2024-12, p.e2412738
issn 0935-9648
1521-4095
1521-4095
language eng
recordid cdi_proquest_miscellaneous_3150345739
source Wiley-Blackwell Read & Publish Collection
title Hyperspectral Metachip-Based 3D Spatial Map for Cancer Cell Screening and Quantification
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T22%3A03%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Hyperspectral%20Metachip-Based%203D%20Spatial%20Map%20for%20Cancer%20Cell%20Screening%20and%20Quantification&rft.jtitle=Advanced%20materials%20(Weinheim)&rft.au=Zhao,%20Zihan&rft.date=2024-12-31&rft.spage=e2412738&rft.pages=e2412738-&rft.issn=0935-9648&rft.eissn=1521-4095&rft_id=info:doi/10.1002/adma.202412738&rft_dat=%3Cproquest_cross%3E3150345739%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c180t-f78a3174cc1e64cf9fd718107d1fc3ee711e2f83616ca143543df8948a9f01c13%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=3150345739&rft_id=info:pmid/39737606&rfr_iscdi=true