Cervical spinal decompression and fusion in the setting of Wolcott-Rallison Syndrome: a rare pediatric indication and its surgical considerations

Wolcott-Rallison Syndrome is an extremely rare syndrome characterized by infantile non-autoimmune diabetes, extensive skeletal dysplasia, and multi-organ failure requiring transplant. Prognosis is very poor, and as such, surgical intervention for symptomatic cervical spine compromise in pediatric pa...

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Bibliographic Details
Published in:Child's nervous system 2025-12, Vol.41 (1), p.74, Article 74
Main Authors: Lu, Victor M., Boddu, James V., Levi, Allan D.
Format: Article
Language:English
Subjects:
Case Report
Cervical Vertebrae - diagnostic imaging
Cervical Vertebrae - surgery
Child
Decompression, Surgical - methods
Epiphyses - abnormalities
Humans
Medicine
Medicine & Public Health
Neurosciences
Neurosurgery
Osteochondrodysplasias - complications
Osteochondrodysplasias - surgery
Spinal Cord Compression - diagnostic imaging
Spinal Cord Compression - etiology
Spinal Cord Compression - surgery
Spinal Fusion - methods
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Description
Summary:Wolcott-Rallison Syndrome is an extremely rare syndrome characterized by infantile non-autoimmune diabetes, extensive skeletal dysplasia, and multi-organ failure requiring transplant. Prognosis is very poor, and as such, surgical intervention for symptomatic cervical spine compromise in pediatric patients has not been widely reported in part due to their high fragility. We report a complex case of Wolcott-Rallison Syndrome that presented with cervical myelopathy due to cervicomedullary compression and the exceptional surgical considerations required for successful intervention.
ISSN:0256-7040
1433-0350
1433-0350
DOI:10.1007/s00381-024-06744-7