Initial antigen encounter determines robust T-cell immunity against SARS-CoV-2 BA.2.86 variant three years later

We aimed to evaluate the adaptive immune responses' cross-recognition of the hypermutated SARS-CoV-2 BA.2.86 variant and identify the determinants influencing this recognition. We measured BA.2.86 neutralizing antibodies and T-cell responses cross-reactivity in previously exposed participants....

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Bibliographic Details
Published in:The Journal of infection 2024-12, Vol.90 (2), p.106402, Article 106402
Main Authors: Rubio, Rocío, Yavlinsky, Alexei, Zamudio, Marina Escalera, Molinos-Albert, Luis M, Pérez, Carla Martín, Pradenas, Edwards, Canyelles, Mar, Torres, Cèlia, Tan, Cedric, Swadling, Leo, Ramírez-Morros, Anna, Trinité, Benjamin, Vidal-Alaball, Josep, Aguilar, Ruth, Ruiz-Comellas, Anna, Blanco, Julià, van Dorp, Lucy, Balloux, François, Dobaño, Carlota, Moncunill, Gemma
Format: Article
Language:English
Subjects:
BA.2.86 cross-recognition
COVID-19
neutralizing antibodies
Pirola
T cells
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Summary:We aimed to evaluate the adaptive immune responses' cross-recognition of the hypermutated SARS-CoV-2 BA.2.86 variant and identify the determinants influencing this recognition. We measured BA.2.86 neutralizing antibodies and T-cell responses cross-reactivity in previously exposed participants. We investigated clinic-demographic factors and used a novel in silico analysis to assess viral genetic determinants affecting T-cell responses. Despite notable escape from neutralizing antibodies, T-cell responses remained generally preserved, albeit with a significant but small loss in T-cell cross-recognition (7.5%, 14.2%, and 10.8% average loss for IFN-γ, IL-2, and IFN-γ + IL-2, respectively, p
ISSN:0163-4453
1532-2742
1532-2742
DOI:10.1016/j.jinf.2024.106402