Relationship between systemic immune-inflammation index and depression among individuals with and without cardiovascular disease

• Published in: Journal of cardiothoracic surgery 2025-01, Vol.20 (1), p.15
• Main Authors: Liu, Dan, He, Chaojie, Luo, Xinguo
• Format: Article
• Language: English
• ISSN: 1749-8090; 1749-8090
• DOI: 10.1186/s13019-024-03314-5

Depression is a common comorbidity in cardiovascular disease (CVD), and both conditions are associated with chronic inflammation. The systemic immune-inflammation index (SII) has emerged as a promising marker of systemic inflammation, but its role in association with depressive symptoms, particularly in the context of CVD, remains unclear. This study aims to investigate the association of SII with depressive symptoms in individuals with and without CVD using cross-sectional data from NHANES (2005-2016).OBJECTIVEDepression is a common comorbidity in cardiovascular disease (CVD), and both conditions are associated with chronic inflammation. The systemic immune-inflammation index (SII) has emerged as a promising marker of systemic inflammation, but its role in association with depressive symptoms, particularly in the context of CVD, remains unclear. This study aims to investigate the association of SII with depressive symptoms in individuals with and without CVD using cross-sectional data from NHANES (2005-2016).A total of 29,479 participants from the National Health and Nutrition Examination Survey (NHANES) 2005-2016 waves were included. Depressive symptoms were assessed through Patient's Health Questionnaire (PHQ-9). SII was calculated as the platelet count × neutrophil count/lymphocyte count. In order to determine the relationships between SII and depressive symptoms in participants with and without CVD, binary logistic regression model and smooth curve fitting were used. We also performed sensitivity analyses and subgroup analysis.METHODSA total of 29,479 participants from the National Health and Nutrition Examination Survey (NHANES) 2005-2016 waves were included. Depressive symptoms were assessed through Patient's Health Questionnaire (PHQ-9). SII was calculated as the platelet count × neutrophil count/lymphocyte count. In order to determine the relationships between SII and depressive symptoms in participants with and without CVD, binary logistic regression model and smooth curve fitting were used. We also performed sensitivity analyses and subgroup analysis.The total prevalence of depressive symptoms was 8.73% among the 29,479 participants analyzed. After adjusting for confounding factors, a higher SII was significantly associated with increased depressive symptoms in the total population (OR per SD increase: 1.101, 95% CI: 1.060-1.144, P