Anthelmintic Potential of Conjugated Long-Chain Fatty Acids Isolated from the Bioluminescent Mushroom Neonothopanus gardneri

• Published in: Journal of natural products (Washington, D.C.) D.C.), 2025-01
• Main Authors: Oliveira, Maria D A, Dos S Andrade, Teresinha de Jesus A, Junior, Joaquim S C, Lima, Nerilson Marques, Machado, Hugo G, Tabudravu, Jioji N, Pinto, Francisco das Chagas L, Fukui-Silva, Lucas, Amaro, Monique C, de Moraes, Josué, Silva, Dulce Helena S, Citó, Antônia Maria das Graças L, Feitosa, Chistiane Mendes
• Format: Article
• Language: English
• ISSN: 0163-3864; 1520-6025; 1520-6025
• DOI: 10.1021/acs.jnatprod.4c00546

With praziquantel being the sole available drug for schistosomiasis, identifying novel anthelmintic agents is imperative. A chemical investigation of the fruiting body of the bioluminescent mushroom Berk. resulted in the isolation of new conjugated long-chain fatty acids (8 ,10 ,12 ,13 )-12,13-dihydroxy-7-oxo-octadeca-8,10-dienoic acid ( ) and (7 ,8 ,9 ,11 )-7,8-dihydroxy-13-oxo-octadeca-9,11-dienoic acid ( ) and three previously described compounds, (7 ,8 ,9 )-7,8-dihydroxyoctadec-9-enoic acid ( ), (2 )-dec-2-ene-1,10-dioic acid ( ), and a ketolactone marasmeno-1,15-dione ( ). Their planar structures were elucidated based on 1D and 2D NMR and MS/MS spectroscopic analyses. Compound displayed significant antiparasitic activity against (EC < 10 μM). No toxicity was observed in mammalian cells or .