Novel coatings for the continuous repair of human bone defects

Bone defects are the second most common tissue grafts after blood. However, bone grafts face several problems, such as bone scaffolds, which have low bioactivity and are prone to corrosion. Much of the current research on bone scaffolds is focused on the mechanical aspects such as structure and stre...

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Bibliographic Details
Published in:Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2023-02, Vol.222, p.113127-113127, Article 113127
Main Authors: Zhou, Guangzhen, Wang, Fei, Lin, Guimei, Tang, Bingtao, Li, Xuelin, Ding, Xinbing, Wang, Wenguang, Zhang, Jing, Shi, Yanbin
Format: Article
Language:English
Subjects:
adhesion
bioactive properties
Bioactivity
Bionic structures
blood
Bone and Bones
Coating
corrosion
Humans
immune response
Mechanical properties
medicine
Porosity
Scaffolds
synergism
Tissue Scaffolds - chemistry
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Summary:Bone defects are the second most common tissue grafts after blood. However, bone grafts face several problems, such as bone scaffolds, which have low bioactivity and are prone to corrosion. Much of the current research on bone scaffolds is focused on the mechanical aspects such as structure and strength. Surface modification of the bone scaffold is carried out in terms of the mechanical structure or structural design of the bone scaffold with reference to a bionic structure. However, with the development of mechanical designs, materials science, and medicine, many studies have reported that promoting bone growth by modifying the structure of the scaffold or coating is not possible. Therefore, the application of a bioactive coating to the surface of the bone scaffold is particularly important to generate a synergistic effect between the structure and active coating. In this article, we present several perspectives to improve the bioactivity of bone scaffolds, including corrosion resistance, loading of bioactive coatings or drugs on bone scaffolds, improved adhesion to the surface of the bone scaffolds, immune response modulation, and drawing on bionic structures during manufacturing. [Display omitted] •Improving the bioactivity of bone scaffold coatings through different ideas.•The specific mechanism of action of bioactive coatings made of different materials.•Advantages of bionic structures in coating and scaffolding applications.•Future trends in bioactive and drug-carrying coatings.
ISSN:0927-7765
1873-4367
DOI:10.1016/j.colsurfb.2023.113127