Pharmacokinetics of meloxicam following intravenous administration at different doses in sheep

• Published in: Journal of veterinary pharmacology and therapeutics 2024-05, Vol.47 (3), p.202-207
• Main Authors: Gungor, Huseyin, Corum, Orhan, Durna Corum, Duygu, Kumru, Alper Serhat, Yilmaz, Gökhan, Coskun, Devran, Coskun, Alparslan, Uney, Kamil
• Format: Article
• Language: English
• Subjects: Administration, Intravenous - veterinary; Animals; Anti-Inflammatory Agents, Non-Steroidal - administration & dosage; Anti-Inflammatory Agents, Non-Steroidal - blood; Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics; Area Under Curve; Dose-Response Relationship, Drug; Female; Half-Life; increasing dose; Injections, Intravenous - veterinary; intravenous injection; Male; meloxicam; Meloxicam - administration & dosage; Meloxicam - blood; Meloxicam - pharmacokinetics; pharmacokinetics; sheep; Sheep - blood
• ISSN: 0140-7783; 1365-2885
• DOI: 10.1111/jvp.13422

The aim of this study is to determine the pharmacokinetic change after intravenous administration of meloxicam at doses of 0.5, 1 and 2 mg/kg to sheep. The study was carried out on six Akkaraman sheep. Meloxicam was administered intravenously to each sheep at 0.5, 1, and 2 mg/kg doses in a longitudinal pharmacokinetic design with a 15‐day washout period. Plasma concentrations of meloxicam were determined using the high performance liquid chromatography‐ultraviolet, and pharmacokinetic parameters were evaluated by non‐compartmental analysis. Meloxicam was detected up to 48 h in the 0.5 mg/kg dose and up to 96 h in the 1 and 2 mg/kg doses. As the dose increased from 0.5 to 2 mg/kg, terminal elimination half‐life, and dose normalized area under the concentration versus time curve increased and total clearance decreased. Compared to the 1 mg/kg dose, it was determined that Vdss decreased and C0.083h increased in the 2 mg/kg dose. Meloxicam provided the therapeutic concentration of >0.39 μg/mL reported in other species for 12, 48 and 96 h at 0.5, 1 and 2 mg/kg doses, respectively. These results show that meloxicam exhibits non‐linear pharmacokinetics and will achieve unpredictable plasma concentrations when administered IV for a rapid effect at dose of ≥1 mg/kg in sheep.