In vitro anticholinergic and antiglycaemic properties of frost-hardy Actinidia fruit extracts and their polyphenol profile, L-ascorbic acid content and antioxidant capacity

[Display omitted] •‘Lande’ fruit extract revealed the highest anti-AChE activity.•‘Skarlet September Kiwi’ fruit extract had a strong anti-AGEs effect.•‘Lande’ showed the highest TPC, TFC, ABTS and DPPH values.•(+)-catechin and L-ascorbic acid highly correlated with anti-AChE parameter. The aim of t...

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Published in:Food research international 2023-11, Vol.173, p.113324-113324, Article 113324
Main Authors: Sawicki, Tomasz, Błaszczak, Wioletta, Latocha, Piotr
Format: Article
Language:English
Subjects:
acetylcholinesterase
Actinidia arguta
Actinidia kolomikta
advanced glycation end products
antioxidant activity
ascorbic acid
food research
fruits
polyphenols
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Summary:[Display omitted] •‘Lande’ fruit extract revealed the highest anti-AChE activity.•‘Skarlet September Kiwi’ fruit extract had a strong anti-AGEs effect.•‘Lande’ showed the highest TPC, TFC, ABTS and DPPH values.•(+)-catechin and L-ascorbic acid highly correlated with anti-AChE parameter. The aim of this study was to investigate the inhibitory effects of Actinidia arguta (‘Weiki’, ‘Skarlet September Kiwi’) and Actinidia kolomikta (‘Lande’) fruit extracts against advanced glycation end-products (AGEs) formation and acetylcholinesterase (AChE) activity. The extracts were also tested regarding polyphenol profile and Lascorbic acid content (UHPLC-DAD-MS), and antioxidant capacity (DPPH, ABTS). ‘Scarlet September Kiwi’ showed the strongest anti-AGEs activity studied with BSAGLU (IC50 = 2.68) and BSA-MGO (IC50 = 18.06) models. The highest anti-AChE activity was found for the ‘Lande’ extract (IC50 = 4.56). ‘Lande’ showed the highest L-ascorbic acid content (8271.96 µg/g dw), ABTS (312.42 µmol TE/g dw) and DPPH (282.01 µmol TE/g dw) values. 'Scarlet September Kiwi' revealed the highest individual phenolics concentration (2321.43 µg/g dw). The contents of (+)-catechin and L-ascorbic acid were significantly correlated with anti-AChE activity. This research sheds new light on the bioactivity of Actinidia arguta and Actinidia kolomikta fruit elucidating the role of (+)-catechin and L-ascorbic acid in prevention of Alzheimer’s disease.
ISSN:0963-9969
1873-7145
DOI:10.1016/j.foodres.2023.113324